SLC1A4 and ERVW-1

Number of citations of the paper that reports this interaction (PubMedID 12050356)
63

Data Source:
HPRD (in vivo, in vitro)

		SLC1A4	ERVW-1
Description		solute carrier family 1 member 4	endogenous retrovirus group W member 1, envelope
Image
GO Annotations	Cellular Component	Centrosome Intermediate Filament Plasma Membrane Cell Surface Membrane Dendrite Melanosome Neuronal Cell Body Synapse Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Chloride Channel Activity Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-proline Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity L-threonine Transmembrane Transporter Activity Symporter Activity L-hydroxyproline Transmembrane Transporter Activity
	Biological Process	Amino Acid Transport Glutamine Transport L-alanine Transport L-cystine Transport L-glutamate Transmembrane Transport Proline Transport L-serine Transport Threonine Transport Hydroxyproline Transport Synaptic Transmission, Glutamatergic Proline Transmembrane Transport Cognition Serine Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport L-serine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane	Syncytium Formation By Plasma Membrane Fusion Syncytium Formation Myoblast Fusion Anatomical Structure Morphogenesis
Pathways		Amino acid transport across the plasma membrane
Drugs		Alanine
Diseases
GWAS		Atrial fibrillation ( 28416822) Ejection fraction ( 29403010) Fractional shortening ( 29403010) Left ventricular internal dimension in systole ( 29403010) Macular telangiectasia type 2 ( 33654266) Metabolite levels ( 22286219 22916037) Pulse pressure ( 27841878) Serum metabolite levels ( 33031748) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		3 interacting genes: CREBBP ERVW-1 F2RL1	2 interacting genes: SLC1A4 SLC1A5
Entrez ID		6509	30816
HPRD ID		02576	05231
Ensembl ID		ENSG00000115902	ENSG00000242950
Uniprot IDs		P43007	D0EYG5 Q9UQF0
PDB IDs		7P4I	5HA6 6RX1 8OUH 8OUJ
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Killing Of Cells Of Another Organism MRF Binding Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Peptidyl-lysine Acetylation Regulation Of Innate Immune Response Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Protein Localization N-terminal Protein Amino Acid Acetylation Positive Regulation Of Defense Response Regulation Of Toll-like Receptor 3 Signaling Pathway Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Phagocytosis, Engulfment Regulation Of Glomerular Filtration Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Defense Response To Bacterium Regulation Of Superoxide Anion Generation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Cell-cell Junction Maintenance Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Depolymerization G-protein Beta-subunit Binding Pseudopodium Positive Regulation Of Immune Response Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity	L-serine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity Glutamine Transport Serine Transport L-aspartate Transmembrane Transport L-aspartate Import Across Plasma Membrane L-serine Transport L-aspartate Transmembrane Transporter Activity Aspartate Transmembrane Transport Neutral L-amino Acid Transmembrane Transporter Activity C4-dicarboxylate Transport Amino Acid Transmembrane Transporter Activity Amino Acid Import Across Plasma Membrane Neutral Amino Acid Transport L-alpha-amino Acid Transmembrane Transport L-amino Acid Transport Dicarboxylic Acid Transport Transport Across Blood-brain Barrier Organic Cation Transport Amino Acid Transmembrane Transport Symporter Activity Melanosome Amino Acid Transport Organic Acid Transmembrane Transport Carboxylic Acid Transmembrane Transport Import Across Plasma Membrane Hydroxyproline Transport L-hydroxyproline Transmembrane Transporter Activity L-threonine Transmembrane Transporter Activity Threonine Transport Carboxylic Acid Transport Organic Acid Transport Glutamine Secretion Vascular Process In Circulatory System Serine Import Across Plasma Membrane L-serine Import Across Plasma Membrane Circulatory System Process Organic Anion Transport L-proline Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity L-alanine Import Across Plasma Membrane Ligand-gated Channel Activity L-alanine Transmembrane Transport L-glutamine Import Across Plasma Membrane L-alanine Transmembrane Transporter Activity Proline Transmembrane Transport L-cystine Transport L-alanine Transport Proline Transport Import Into Cell
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