SLC1A4

Description		solute carrier family 1 member 4
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GO Annotations	Cellular Component	Centrosome Intermediate Filament Plasma Membrane Cell Surface Membrane Dendrite Melanosome Neuronal Cell Body Synapse Extracellular Exosome
	Molecular Function	Chloride Channel Activity Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-cystine Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-proline Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity L-threonine Transmembrane Transporter Activity Symporter Activity L-hydroxyproline Transmembrane Transporter Activity
	Biological Process	Amino Acid Transport Glutamine Transport L-alanine Transport L-cystine Transport L-glutamate Transmembrane Transport Proline Transport L-serine Transport Threonine Transport Hydroxyproline Transport Synaptic Transmission, Glutamatergic Proline Transmembrane Transport Cognition Serine Import Across Plasma Membrane L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier Chloride Transmembrane Transport L-serine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways		Amino acid transport across the plasma membrane
Drugs		Alanine
Diseases
GWAS		Atrial fibrillation ( 28416822) Ejection fraction ( 29403010) Fractional shortening ( 29403010) Left ventricular internal dimension in systole ( 29403010) Macular telangiectasia type 2 ( 33654266) Metabolite levels ( 22286219 22916037) Pulse pressure ( 27841878) Serum metabolite levels ( 33031748) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		3 interacting genes: CREBBP ERVW-1 F2RL1
Entrez ID		6509
HPRD ID		02576
Ensembl ID		ENSG00000115902
Uniprot IDs		P43007
PDB IDs		7P4I
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Killing Of Cells Of Another Organism MRF Binding Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Peptidyl-lysine Acetylation Regulation Of Innate Immune Response Negative Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Protein Localization N-terminal Protein Amino Acid Acetylation Positive Regulation Of Defense Response Regulation Of Toll-like Receptor 3 Signaling Pathway Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Actin Filament Depolymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Phagocytosis, Engulfment Regulation Of Glomerular Filtration Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Defense Response To Bacterium Regulation Of Superoxide Anion Generation Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Cell-cell Junction Maintenance Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Depolymerization G-protein Beta-subunit Binding Pseudopodium Positive Regulation Of Immune Response Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity
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