PINK1 and PGAM5

Number of citations of the paper that reports this interaction (PMID 21151955)
23

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PINK1	PGAM5
Gene Name		PTEN induced putative kinase 1	phosphoglycerate mutase family member 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Membrane Axon Integral Component Of Mitochondrial Outer Membrane TORC2 Complex Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Protease Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Calcium-dependent Protein Kinase Activity Kinase Activity Peptidase Activator Activity Ubiquitin Protein Ligase Binding Protein Kinase B Binding C3HC4-type RING Finger Domain Binding	Phosphoprotein Phosphatase Activity GTPase Activator Activity Phosphatase Activity Protein Complex Binding
	Biological Process	Mitochondrion Degradation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Respiratory Electron Transport Chain Regulation Of Protein Ubiquitination Activation Of Protein Kinase B Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Dopamine Secretion Cellular Response To Oxidative Stress Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Peptidyl-serine Autophosphorylation TORC2 Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Negative Regulation Of JNK Cascade Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Transport Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Dephosphorylation Positive Regulation Of GTPase Activity Necroptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BAG2 CRLS1 EED FBXO7 MAP3K7 MARK2 PARK7 PGAM5 SNCA SNCAIP TRAF6 UBC UBE2M	5 interactors: HSPA1B PINK1 SETDB1 YWHAG ZBTB16
Entrez ID		65018	192111
HPRD ID		10514	14681
Ensembl ID		ENSG00000158828	ENSG00000247077
Uniprot IDs		Q9BXM7	Q96HS1
PDB IDs			3MXO 3O0T
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Cellular Response To Growth Factor Stimulus Cell Death Death Toll-like Receptor 4 Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Oxidative Phosphorylation JNK Cascade Dopamine Transport Cellular Metabolic Process Regulation Of Cellular Respiration Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway	Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Apoptotic Process Regulation Of Cell Death Protein Stabilization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Cellular Heat Acclimation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Myeloid Cell Differentiation Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Cellular Response To Hypoxia Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Dopamine Secretion Male Germ-line Stem Cell Asymmetric Division Peptidyl-serine Autophosphorylation Negative Regulation Of Gene Expression Regulation Of Synaptic Transmission Negative Regulation Of Oxidative Stress-induced Neuron Death TORC2 Signaling Positive Regulation Of Mitochondrial Fission Histone H3-K9 Trimethylation Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Oxidative Phosphorylation Negative Regulation Of Inclusion Body Assembly Regulation Of Mitochondrion Degradation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Catecholamine Secretion Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Mitochondrial Fission Regulation Of Cellular Respiration Regulation Of Cell Differentiation Negative Regulation Of Phosphorylation Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Organelle Organization Response To Oxidative Stress Regulation Of Metabolic Process
Tagcloud ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	activates advances atg atg11 atg32 atg8 bnip3 bnip3l casein catabolic ck2 classic damaged dephosphorylates fccp fundc1 homolog lc3 mammalian mammals mitochondria mitophagy nix notably phosphorylate phosphorylates reversible unwanted yeast
Tagcloud (Difference) ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	activates advances atg atg11 atg32 atg8 bnip3 bnip3l casein catabolic ck2 classic damaged dephosphorylates fccp fundc1 homolog lc3 mammalian mammals mitochondria mitophagy nix notably phosphorylate phosphorylates reversible unwanted yeast
Tagcloud (Intersection) ?