CDCP1 and ST14

Number of citations of the paper that reports this interaction (PubMedID 16007225)
44

Data Source:
HPRD (in vivo)

		CDCP1	ST14
Description		CUB domain containing protein 1	ST14 transmembrane serine protease matriptase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process		Neural Tube Closure Proteolysis Protein Catabolic Process Keratinocyte Differentiation Epithelial Cell Differentiation Animal Organ Development Epithelial Cell Morphogenesis Involved In Placental Branching
Pathways			Formation of the cornified envelope Formation of the cornified envelope
Drugs			Urokinase Benzamidine Camostat
Diseases			Ichthyosis with hypotrichosis
GWAS		Achilles tendon injury ( 33606446) Acne (severe) ( 24927181) Blood protein levels ( 30072576) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Macular thickness ( 30535121) Metabolite levels ( 23823483) Statin-induced myopathy (severe) ( 31220337)	Adverse response to drug ( 30420678) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		6 interacting genes: CLK1 PLG PRKCD SDCBP SRC ST14	16 interacting genes: AKT1 APC CASP8 CDCP1 CDKN2C CHEK2 F2RL1 HGF PDGFC PHB1 PLAU RAD51 RGS16 SPINT1 STK11 TGFB1
Entrez ID		64866	6768
HPRD ID		16696	06005
Ensembl ID		ENSG00000163814	ENSG00000149418
Uniprot IDs		Q9H5V8	Q9Y5Y6
PDB IDs			1EAW 1EAX 2GV6 2GV7 3BN9 3NCL 3NPS 3P8F 3P8G 3SO3 4IS5 4ISL 4ISN 4ISO 4JYT 4JZ1 4JZI 4O97 4O9V 4R0I 5LYO 6N4T 6T9T 8G1V 8G1W
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activator Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Neutrophil Activation Fc-gamma Receptor Signaling Pathway Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Adhesion Negative Regulation Of Hemostasis Positive Regulation Of Phosphate Metabolic Process Fc Receptor Signaling Pathway Enzyme Binding Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Cellular Response To Hydrogen Peroxide Interleukin-5 Receptor Complex Azurophil Granule Lumen Protein Kinase Activity Regulation Of Cell-cell Adhesion Positive Regulation Of Sphingomyelin Catabolic Process Response To Hydrogen Peroxide Regulation Of Organelle Organization Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Localization To Nucleus Interleukin-5 Receptor Binding Positive Regulation Of Organelle Assembly Positive Regulation Of Organelle Organization Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Cell Migration Blood Microparticle Positive Regulation Of Cell Motility Serine-type Peptidase Activity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Myeloid Leukocyte Activation Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Epithelial Cell Morphogenesis Involved In Placental Branching Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Locomotion Regulation Of Wound Healing	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Migration Regulation Of Multicellular Organismal Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Cycle Phase Transition Cell Population Proliferation Regulation Of Cell Cycle Regulation Of Locomotion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Growth Response To Glycoside Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Response To Stress Regulation Of Cell Growth Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Cell Population Proliferation Cellular Response To Ionizing Radiation Positive Regulation Of Protein Localization Response To Radiation Positive Regulation Of Cellular Component Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Negative Regulation Of Growth Negative Regulation Of Intracellular Signal Transduction Anoikis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Defense Response Positive Regulation Of MAPK Cascade
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