ILRUN and RPSA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ILRUN	RPSA
Description		inflammation and lipid regulator with UBA-like and NBR1-like domains	ribosomal protein SA
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleus Cytoplasm Centrosome Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Ribosome Plasma Membrane Small Ribosomal Subunit Membrane Cytosolic Ribosome Cytosolic Small Ribosomal Subunit Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Ubiquitin Binding	Virus Receptor Activity DNA Binding RNA Binding Structural Constituent Of Ribosome Laminin Receptor Activity Protein Binding Ribosome Binding Laminin Binding
	Biological Process	Immune System Process Macroautophagy Negative Regulation Of Type I Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of DNA Binding Innate Immune Response Negative Regulation Of Defense Response To Virus Negative Regulation Of Protein Localization To Nucleus	Ribosomal Small Subunit Assembly Cytoplasmic Translation Chromatin Remodeling Translation Cell Adhesion Symbiont Entry Into Host Cell Antiviral Innate Immune Response
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency SARS-CoV-1 modulates host translation machinery SARS-CoV-2 modulates host translation machinery Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			Tigapotide Copper
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Dentate gyrus volume x schizophrenia interaction ( 31155012)
Interacting Genes		5 interacting genes: APP FBXO25 MAP3K1 RPSA SMURF1	37 interacting genes: ABCD1 ACADVL ACD ANKH CALM2 CBX5 CCDC13 CLEC4G CSF2RA DCTN6 EIF3E FILNC1 GNMT HBG2 HNRNPD HSPB1 IL7R ILRUN ITGA6 KARS1 LAMA2 LINC01554 NKX3-1 OGT PDE4B PEA15 POT1 PRND PROS1 RNF114 RPS21 SLC2A5 SUMO4 TINF2 TRIB3 TSC2 USP2-AS1
Entrez ID		64771	3921
HPRD ID		12837	01038
Ensembl ID		ENSG00000196821	ENSG00000168028
Uniprot IDs		Q9H6K1	A0A0C4DG17 P08865
PDB IDs		6VHI	3BCH 4UG0 4V5Z 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6FEC 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZUO 6ZV6 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I 7QP6 7QP7 7QVP 7R4X 7TQL 7WTV 7WTW 7WTX 7WTZ 7WU0 7XNX 7XNY 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IFD 8IFE 8JDJ 8JDK 8JDL 8JDM 8K2C 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPK 8PPL 8QOI 8RG0 8T4S 8UKB 8XP2 8XP3 8XSX 8XSY 8XSZ 8XXL 8XXM 8XXN 8Y0W 8Y0X 8YOO 8YOP 8ZDB 8ZDC 8ZDD 9BKD 9BLN 9C3H 9G8M 9G8O
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Protein Metabolic Process Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Response To Mechanical Stimulus Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Laminin Receptor Activity Engulfment Of Target By Autophagosome Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Macromolecule Metabolic Process Activin Receptor Binding Axon Choice Point Recognition Ubiquitin-protein Transferase Activity Heparan Sulfate Binding Signaling Receptor Activator Activity Substrate Localization To Autophagosome Peptidase Activator Activity Cellular Response To Manganese Ion Axon Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding	Telomere Assembly Shelterin Complex Telomeric DNA Binding Nuclear Telomere Cap Complex Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Translational Initiation Fructose Binding Telomerase Inhibitor Activity Negative Regulation Of Telomere Maintenance Establishment Of Protein Localization To Telomere Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Translational Initiation Negative Regulation Of Biosynthetic Process Response To Sodium Phosphate Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Insulin Receptor Signaling Pathway Chromosome, Telomeric Region Urogenital System Development Regulation Of Small Molecule Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Binding Regulation Of Lipid Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Translation Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Response To Salt Regulation Of T Cell Differentiation In Thymus RNA-templated DNA Biosynthetic Process Telomere Maintenance Very Long-chain Fatty-acyl-CoA Catabolic Process Negative Regulation Of Macromolecule Metabolic Process ABC-type Fatty-acyl-CoA Transporter Activity Hepatocyte Dedifferentiation Regulation Of Translation Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Putrescine
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