SHH and PTCH1

Number of citations of the paper that reports this interaction (PMID 9811851)
27

Data Source:
HPRD (in vivo)

		SHH	PTCH1
Gene Name		sonic hedgehog	patched 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Extracellular Matrix Membrane Raft	Golgi Apparatus Plasma Membrane Caveola Postsynaptic Density Integral Component Of Membrane Midbody Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Ciliary Membrane Primary Cilium
	Molecular Function	Glycoprotein Binding Patched Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Peptidase Activity Zinc Ion Binding Morphogen Activity Laminin-1 Binding	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein Complex Binding Hedgehog Family Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Patterning Of Blood Vessels Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Neural Crest Cell Migration Heart Looping Positive Regulation Of Neuroblast Proliferation Osteoblast Development Lymphoid Progenitor Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Proteolysis Endocytosis Smoothened Signaling Pathway Positive Regulation Of Hh Target Transcription Factor Activity Cell-cell Signaling Pattern Specification Process Ectoderm Development Neuroblast Proliferation Axon Guidance Central Nervous System Development Ventral Midline Development Hindgut Morphogenesis Heart Development Blood Coagulation Androgen Metabolic Process Positive Regulation Of Cell Proliferation Embryo Development Embryonic Pattern Specification Polarity Specification Of Anterior/posterior Axis Dorsal/ventral Pattern Formation Oligodendrocyte Development Striated Muscle Tissue Development Positive Regulation Of Skeletal Muscle Cell Proliferation Myotube Differentiation Intein-mediated Protein Splicing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Thalamus Development Dorsal/ventral Neural Tube Patterning Cerebellar Granule Cell Precursor Proliferation Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Telencephalon Regionalization Establishment Of Cell Polarity Regulation Of Proteolysis Positive Regulation Of Wnt Signaling Pathway Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Male Genitalia Development Prostate Gland Development Thyroid Gland Development Forebrain Development Midbrain Development Hindbrain Development Pancreas Development Hair Follicle Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Regulation Of Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Embryonic Digit Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Thymic T Cell Selection Negative Thymic T Cell Selection Intermediate Filament Organization Myoblast Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Cell Development Thymus Development Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Organ Formation Neuron Fate Commitment Embryonic Skeletal System Development Positive Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Formation Of Anatomical Boundary Stem Cell Development Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division Bergmann Glial Cell Differentiation Palate Development Canonical Wnt Signaling Pathway Limb Bud Formation Lung Epithelium Development Trachea Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Right Lung Development Left Lung Development Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Primary Prostatic Bud Elongation Prostate Epithelial Cord Elongation Salivary Gland Cavitation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Regulation Of Prostatic Bud Formation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Artery Development Mesenchymal Cell Proliferation Involved In Lung Development Somite Development Positive Regulation Of Sclerotome Development Cellular Response To Lithium Ion Renal System Development Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Multicellular Structure Septum Development Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cholesterol Efflux Apoptotic Signaling Pathway Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Regulation Of Protein Localization To Nucleus Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Apoptotic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Smoothened Signaling Pathway Regulation Of Mitotic Cell Cycle Brain Development Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Organ Morphogenesis Dorsal/ventral Pattern Formation Response To Chlorate Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinocyte Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Embryonic Organ Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Renal System Development Cell Proliferation Involved In Metanephros Development Protein Targeting To Plasma Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Metabolic disorders of biological oxidation enzymes GPCR ligand binding Ligand-receptor interactions Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Corneal astigmatism ( 23322567) Platelet aggregation ( 20526338)	Height ( 18391952) Pulmonary function ( 20010835) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		5 interactors: ADCYAP1 GAS1 HHIP PTCH1 PTCH2	7 interactors: CCNB1 CDK1 DHH HIPK2 IHH SHH SMO
Entrez ID		6469	5727
HPRD ID		02838	03200
Ensembl ID			ENSG00000185920
Uniprot IDs		Q15465	Q13635 Q59FG5
PDB IDs		3HO5 3M1N 3MXW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Dorsal/ventral Neural Tube Patterning Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signaling Neural Tube Patterning Pattern Specification Process Generation Of Neurons Neurogenesis Tissue Development Positive Regulation Of Somatostatin Secretion Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Cell Proliferation Smoothened Signaling Pathway Tube Development Negative Regulation Of Epithelial Cell Proliferation Brain Development Head Development Anatomical Structure Development Neural Plate Axis Specification Response To Chlorate Nervous System Development Embryonic Limb Morphogenesis Regulation Of Cell Cycle Limb Morphogenesis Central Nervous System Development Neural Tube Development Developmental Process Limb Development Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Morphogenesis Of A Branching Epithelium Neuron Differentiation Negative Regulation Of Growth Morphogenesis Of A Branching Structure Organ Development Epidermis Development Skeletal System Morphogenesis Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Growth Hormone Secretion Cellular Response To Stimulus Cell Proliferation Involved In Metanephros Development Cell Differentiation	Muscle Tissue Development Positive Regulation Of Cell Proliferation Smoothened Signaling Pathway Digestive Tract Development Digestive System Development Intein-mediated Protein Splicing Heart Development Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Organ Development Heart Looping Positive Regulation Of Hh Target Transcription Factor Activity Determination Of Heart Left/right Asymmetry Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Embryonic Heart Tube Morphogenesis Cell Fate Commitment Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Positive Regulation Of Stem Cell Proliferation Striated Muscle Tissue Development Tissue Development Muscle Cell Differentiation Embryonic Organ Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Cardiovascular System Development Cell Development Cell Differentiation Response To Organic Cyclic Compound Embryonic Heart Tube Development Cell-cell Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of Cell Death Epithelial-mesenchymal Cell Signaling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation
Tagcloud ?		asked beyond dopaminergic dorsal e14 e15 embryogenesis exclusion gaba ganglion hedgehog immunoreactive interneurons lim mesencephalon midbrain motorneuron neuron neurotoxin notochord persists promotes sonic specification striatum sympathetic trophic ventral vertebrate	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Difference) ?		asked beyond dopaminergic dorsal e14 e15 embryogenesis exclusion gaba ganglion hedgehog immunoreactive interneurons lim mesencephalon midbrain motorneuron neuron neurotoxin notochord persists promotes sonic specification striatum sympathetic trophic ventral vertebrate	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Intersection) ?