SHH and PTCH1

Number of citations of the paper that reports this interaction (PubMedID 9811851)
39

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		SHH	PTCH1
Description		sonic hedgehog signaling molecule	patched 1
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft	Golgi Apparatus Plasma Membrane Caveola Cilium Membrane Midbody Endocytic Vesicle Membrane Dendritic Growth Cone Axonal Growth Cone Apical Part Of Cell Postsynaptic Membrane Perinuclear Region Of Cytoplasm Ciliary Membrane
	Molecular Function	Endopeptidase Activity Patched Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Peptidase Activity Zinc Ion Binding Morphogen Activity Transferase Activity Hydrolase Activity Laminin-1 Binding Metal Ion Binding Cholesterol-protein Transferase Activity	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein-containing Complex Binding Hedgehog Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Neural Crest Cell Migration Kidney Development Hair Follicle Development Vasculature Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Lymphoid Progenitor Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Regulation Of DNA-templated Transcription Proteolysis Protein Import Into Nucleus Endocytosis Smoothened Signaling Pathway Cell-cell Signaling Determination Of Left/right Symmetry Pattern Specification Process Ectoderm Development Neuroblast Proliferation Axon Guidance Central Nervous System Development Ventral Midline Development Hindgut Morphogenesis Heart Development Skeletal Muscle Tissue Development Blood Coagulation Androgen Metabolic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Tissue Development Polarity Specification Of Anterior/posterior Axis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Mesenchymal Cell Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Tissue Development Skeletal Muscle Cell Proliferation Positive Regulation Of Skeletal Muscle Cell Proliferation Myotube Differentiation Cell Migration Intein-mediated Protein Splicing Protein Autoprocessing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Thalamus Development Forebrain Regionalization Dorsal/ventral Neural Tube Patterning Cell Proliferation In External Granule Layer Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Telencephalon Regionalization Regulation Of Proteolysis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Neuron Differentiation Respiratory Tube Development Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Male Genitalia Development Prostate Gland Development Thyroid Gland Development Forebrain Development Midbrain Development Hindbrain Development Pancreas Development Hair Follicle Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Transcription Elongation By RNA Polymerase II Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Tube Development Trunk Neural Crest Cell Migration T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Embryonic Digit Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Skin Development Positive Thymic T Cell Selection Negative Thymic T Cell Selection Intermediate Filament Organization Cell Fate Commitment Myoblast Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Cell Development Animal Organ Development Thymus Development Digestive Tract Morphogenesis Embryonic Digestive Tract Morphogenesis Embryonic Organ Development Developmental Growth Embryonic Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Animal Organ Formation Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Embryonic Skeletal System Development Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Formation Of Anatomical Boundary Stem Cell Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Developmental Process Striated Muscle Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division Bergmann Glial Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Limb Development Limb Bud Formation Regulation Of Glial Cell Proliferation Lung Morphogenesis Lung Epithelium Development Trachea Development Trachea Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Right Lung Development Left Lung Development Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Primary Prostatic Bud Elongation Prostate Epithelial Cord Elongation Salivary Gland Cavitation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Epithelial-mesenchymal Cell Signaling Regulation Of Prostatic Bud Formation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Artery Development Mesenchymal Cell Proliferation Involved In Lung Development Somite Development Positive Regulation Of Sclerotome Development Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Stem Cell Proliferation Regulation Of Stem Cell Proliferation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Negative Regulation Of Cholesterol Efflux Mesenchymal Cell Apoptotic Process Apoptotic Signaling Pathway Self Proteolysis Skeletal Muscle Fiber Differentiation Regulation Of Nodal Signaling Pathway Regulation Of Protein Localization To Nucleus Negative Regulation Of Dopaminergic Neuron Differentiation Tracheoesophageal Septum Formation Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Cell Fate Determination Neural Tube Formation Neural Tube Closure Heart Morphogenesis Signal Transduction Spermatid Development Regulation Of Mitotic Cell Cycle Pattern Specification Process Brain Development Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Xenobiotic Stimulus Response To Mechanical Stimulus Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Epidermal Cell Fate Specification Response To Chlorate Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Dorsal/ventral Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Prostate Gland Development Mammary Gland Development Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Response To Alkaloid Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Smooth Muscle Tissue Development Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Commissural Neuron Axon Guidance Stem Cell Proliferation Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Protein Localization To Plasma Membrane Liver Regeneration Negative Regulation Of Stem Cell Proliferation
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np Formation of lateral plate mesoderm Formation of axial mesoderm Developmental Lineage of Multipotent Pancreatic Progenitor Cells	Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO
Drugs
Diseases		Solitary median maxillary central incisor syndrome Anophthalmia and microphthalmia (A/M) Holoprosencephaly (HPE) Basal cell carcinoma	Holoprosencephaly (HPE) Basal cell carcinoma Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS		Corneal astigmatism ( 23322567) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Macular thickness ( 30535121) Platelet aggregation ( 20526338 29185836)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adventurousness ( 30643258) Alanine aminotransferase levels ( 33547301) Anxiety ( 33859377) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Dental caries (decayed, missing and filled teeth) ( 31533690) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 28869591 30598549) Height ( 25429064 28552196 31562340 18391952 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Macular thickness ( 30535121) Monobrow ( 27182965) Neurociticism ( 29500382) Nonsyndromic cleft lip with cleft palate ( 28232668) Offspring birth weight ( 31043758) Optic disc size ( 31809533) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412)
Interacting Genes		5 interacting genes: ADCYAP1 GAS1 HHIP PTCH1 PTCH2	21 interacting genes: APPBP2 ATG101 ATM CCNB1 CD200R1 CD74 CD79A CDK1 CREB3 DHH FAM209A HIBADH HIPK2 IHH SHH SIGLEC12 SMO STOM TMPRSS2 TSPAN8 YAP1
Entrez ID		6469	5727
HPRD ID		02838	03200
Ensembl ID		ENSG00000164690	ENSG00000185920
Uniprot IDs		Q15465	A0A0C4DGJ5 A0A1W5YLI7 Q13635
PDB IDs		3HO5 3M1N 3MXW 6DMY 6E1H 6N7G 6N7H 6N7K 6OEV 6PJV 6RMG 6RVD 7E2I 7MHZ 7RHQ 7URF	6DMB 6DMO 6DMY 6E1H 6N7G 6N7H 6N7K 6OEU 6OEV 6RMG 6RTW 6RTX 6RTY 6RVC 6RVD
Enriched GO Terms of Interacting Partners?		Hedgehog Family Protein Binding Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Cell Fate Determination Ciliary Membrane Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Regulation Of Epidermis Development Regulation Of Signal Transduction Cell Fate Specification Pituitary Adenylate Cyclase Activating Polypeptide Activity Neural Plate Axis Specification Regulation Of Cell Communication Regulation Of Signaling Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Response To Chlorate Branching Morphogenesis Of An Epithelial Tube Epidermis Development Morphogenesis Of A Branching Epithelium Regulation Of Epithelial Cell Differentiation Morphogenesis Of A Branching Structure Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Growth Hormone Secretion Regulation Of Cell Cycle Developmental Process Patched Binding Neural Tube Formation Cell Proliferation Involved In Metanephros Development Mammary Gland Duct Morphogenesis Metanephric Collecting Duct Development Neural Tube Patterning Dendritic Growth Cone Regionalization Tube Morphogenesis Cell Proliferation Involved In Kidney Development Peptide Hormone Receptor Binding Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Growth Hormone Secretion Activation Of Adenylate Cyclase Activity Negative Regulation Of Multicellular Organism Growth Morphogenesis Of An Epithelium Collecting Duct Development Dorsal/ventral Neural Tube Patterning	Patched Binding Cholesterol-protein Transferase Activity Protein Autoprocessing Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Self Proteolysis Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Somite Development Cyclin B1-CDK1 Complex Intein-mediated Protein Splicing Embryonic Heart Tube Morphogenesis Smooth Muscle Tissue Development Cell Fate Specification Developmental Growth Cell Development Regulation Of Organ Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Epithelial Tube Morphogenesis Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Positive Regulation Of Protein Import Into Nucleus Epithelial-mesenchymal Cell Signaling Cell Population Proliferation Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Differentiation In Thymus Spinal Cord Dorsal/ventral Patterning Anterior/posterior Pattern Specification Positive Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Lymphocyte Activation Regulation Of Growth Ventricular Cardiac Muscle Cell Development Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Viral Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of T Cell Differentiation In Thymus
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