VPS16 and UVRAG

Number of citations of the paper that reports this interaction (PubMedID 18552835)
46

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, imaging technique)
HPRD (in vivo)

		VPS16	UVRAG
Description		VPS16 core subunit of CORVET and HOPS complexes	UV radiation resistance associated
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Axon HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Neuronal Cell Body Recycling Endosome Presynapse Vesicle Tethering Complex	Lytic Vacuole Autophagosome Membrane Chromosome, Centromeric Region Chromosome Cytoplasm Lysosome Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Centrosome Midbody Cytoplasmic Vesicle Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phosphatidylinositol 3-kinase Complex, Class III Phagocytic Vesicle DNA-dependent Protein Kinase Complex
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	SNARE Binding Protein Binding SH3 Domain Binding
	Biological Process	Intracellular Protein Transport Autophagy Vacuole Organization Endosome To Lysosome Transport Protein Transport Endosomal Transport Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Vacuole Fusion, Non-autophagic Autophagosome Maturation	DNA Repair Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Autophagy DNA Damage Response Spindle Organization Chromosome Segregation Centrosome Cycle Regulation Of Autophagy Vesicle-mediated Transport Regulation Of Cytokinesis Receptor Catabolic Process SNARE Complex Assembly Phosphatidylinositol-3-phosphate Biosynthetic Process Protein-containing Complex Organization Symbiont Entry Into Host Cell Maintenance Of Golgi Location Regulation Of Protein Serine/threonine Kinase Activity Multivesicular Body Sorting Pathway Autophagosome Maturation Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Autophagosome Maturation
Pathways		SARS-CoV-2 modulates autophagy	Macroautophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483)	Asthma ( 31619474) HDL cholesterol ( 30275531) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Mean spheric corpuscular volume ( 32888494) Stroke ( 32693751) Thumb osteoarthritis severity (hand Klsum) ( 33055079)
Interacting Genes		18 interacting genes: AKTIP EXOC8 FBXO7 GNG13 HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP STX1A STX7 UBC UVRAG VPS11 VPS18 VPS33A ZNF417	10 interacting genes: CSNK1A1 ITCH MTOR NEDD4 VPS11 VPS16 VPS18 VPS33B YAP1 ZRANB1
Entrez ID		64601	7405
HPRD ID		12259	03929
Ensembl ID		ENSG00000215305	ENSG00000198382
Uniprot IDs		Q9H269	Q9P2Y5
PDB IDs		4BX9	7BL1
Enriched GO Terms of Interacting Partners?		Endosome To Lysosome Transport HOPS Complex Vesicle Organization Vacuolar Transport Lysosomal Transport Endosome Organization Early Endosome To Late Endosome Transport Vesicle-mediated Transport Establishment Of Protein Localization Protein Transport Late Endosome FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Cellular Localization Intracellular Transport Organelle Localization Membrane Docking Vacuole Organization Vesicle Fusion Organelle Membrane Fusion Intracellular Protein Localization Establishment Of Localization In Cell Organelle Fusion Vesicle Docking Lysosome Organization Membrane Fusion Organelle Localization By Membrane Tethering Dynein Light Intermediate Chain Binding CORVET Complex Organelle Organization Vesicle Docking Involved In Exocytosis Membrane Organization Endosomal Transport Lysosome Autophagy Late Endosome Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Intracellular Protein Transport Autophagosome Lysosomal Membrane Endosome Endosome Membrane Cytoplasmic Vesicle Early Endosome Syntaxin Binding Chloride Channel Inhibitor Activity SNARE Binding Cytoplasmic Microtubule Organization Protein Modification By Small Protein Conjugation	CORVET Complex HOPS Complex Vacuole Organization Vesicle Tethering Complex Lysosomal Transport Vacuolar Transport Endosome To Lysosome Transport Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Positive Regulation Of Protein Catabolic Process Catabolic Process Clathrin-coated Vesicle Vesicle Fusion Intracellular Protein Transport Organelle Membrane Fusion Endosome Membrane Protein Modification Process Early Endosome Organelle Fusion Regulation Of Protein Catabolic Process Lysosomal Membrane Late Endosome Membrane Late Endosome Membrane Fusion Regulation Of Protein-containing Complex Assembly Protein Metabolic Process Post-translational Protein Modification Cytoplasmic Vesicle Negative Regulation Of Signal Transduction Lysosome Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Autophagosome Endosome Organization Regulation Of Cellular Component Organization Protein Transport Protein Ubiquitination Autophagosome Assembly Autophagy Autophagosome Organization Vesicle-mediated Transport Vesicle Organization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Proteolysis Intracellular Transport Protein Modification By Small Protein Conjugation
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