NKX2-4 and NOTO

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NKX2-4	NOTO
Description		NK2 homeobox 4	notochord homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development	Heart Looping Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Central Nervous System Development Brain Development Embryonic Pattern Specification Dorsal/ventral Pattern Formation Neuron Differentiation Notochord Development Motile Cilium Assembly Regulation Of Cilium Assembly
Pathways			Formation of axial mesoderm
Drugs
Diseases
GWAS		Adult body size ( 32376654) Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Metabolite levels ( 23823483)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435)
Interacting Genes		1 interacting genes: NOTO	31 interacting genes: ANKRD11 APOBEC1 BAG3 BANP BTF3 CCDC120 CEP19 CHAF1A EIPR1 ETV3L FAM9B FOXD2 FOXH1 GLYCTK HNRNPK IP6K3 KRT34 KRTAP19-7 KRTAP5-6 KRTAP6-1 KRTAP6-3 LDLRAP1 LRP10 MAGED1 MEIS2 NKX2-4 PIH1D2 POU4F2 SBK3 TTC23 UBTFL1
Entrez ID		644524	344022
HPRD ID
Ensembl ID		ENSG00000125816	ENSG00000214513
Uniprot IDs		Q9H2Z4	A8MTQ0
PDB IDs
Enriched GO Terms of Interacting Partners?		Embryonic Pattern Specification Regulation Of Cilium Assembly Dorsal/ventral Pattern Formation Determination Of Bilateral Symmetry Motile Cilium Assembly Notochord Development Heart Looping Embryonic Heart Tube Morphogenesis Determination Of Left/right Symmetry Epithelial Tube Morphogenesis	Intermediate Filament Positive Regulation Of Low-density Lipoprotein Particle Clearance Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Low-density Lipoprotein Particle Clearance
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