NOTO and NKX2-4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NOTO	NKX2-4
Description		notochord homeobox	NK2 homeobox 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Heart Looping Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Central Nervous System Development Brain Development Embryonic Pattern Specification Dorsal/ventral Pattern Formation Neuron Differentiation Notochord Development Motile Cilium Assembly Regulation Of Cilium Assembly	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development
Pathways		Formation of axial mesoderm
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435)	Adult body size ( 32376654) Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Metabolite levels ( 23823483)
Interacting Genes		31 interacting genes: ANKRD11 APOBEC1 BAG3 BANP BTF3 CCDC120 CEP19 CHAF1A EIPR1 ETV3L FAM9B FOXD2 FOXH1 GLYCTK HNRNPK IP6K3 KRT34 KRTAP19-7 KRTAP5-6 KRTAP6-1 KRTAP6-3 LDLRAP1 LRP10 MAGED1 MEIS2 NKX2-4 PIH1D2 POU4F2 SBK3 TTC23 UBTFL1	1 interacting genes: NOTO
Entrez ID		344022	644524
HPRD ID
Ensembl ID		ENSG00000214513	ENSG00000125816
Uniprot IDs		A8MTQ0	Q9H2Z4
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Positive Regulation Of Low-density Lipoprotein Particle Clearance Microtubule Anchoring At Centrosome Microtubule Anchoring At Microtubule Organizing Center Low-density Lipoprotein Particle Clearance	Embryonic Pattern Specification Regulation Of Cilium Assembly Dorsal/ventral Pattern Formation Determination Of Bilateral Symmetry Motile Cilium Assembly Notochord Development Heart Looping Embryonic Heart Tube Morphogenesis Determination Of Left/right Symmetry Epithelial Tube Morphogenesis
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Tagcloud (Intersection) ?