INF2 and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		INF2	BDKRB2
Description		inverted formin 2	bradykinin receptor B2
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GO Annotations	Cellular Component	Cytoplasm Actin Filament Perinuclear Region Of Cytoplasm	Endosome Plasma Membrane Membrane
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	Protease Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Mitochondrial Fission	System Process Smooth Muscle Contraction Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonate Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant Labradimil
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS			Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		3 interacting genes: BDKRB2 CSNK2A1 UBE2R2	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		64423	624
HPRD ID		08648	00213
Ensembl ID		ENSG00000203485	ENSG00000168398
Uniprot IDs		Q27J81	P30411
PDB IDs		8RV2 9AZ4 9AZP 9AZQ 9B03 9B0K 9FJN 9FJW	7F2O 7F6H 7F6I
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Bradykinin Receptor Activity Negative Regulation Of Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Intrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Type 1 Angiotensin Receptor Binding Protein Stabilization Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Matrix Side Of Mitochondrial Inner Membrane Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Response To Osmotic Stress Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Protein Stability Regulation Of Response To Osmotic Stress MRNA Methylguanosine-cap Decapping Intracellular Signal Transduction Arachidonate Secretion Response To Salt Stress RNA Decapping Mitochondrial Cytochrome C Oxidase Assembly Regulation Of Cellular Response To Stress Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Sin3-type Complex Respiratory Chain Complex IV Assembly Execution Phase Of Apoptosis Protein Localization To Site Of Double-strand Break PcG Protein Complex Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Vasodilation Protein Serine/threonine Kinase Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of The Force Of Heart Contraction Regulation Of Blood Pressure Receptor-mediated Endocytosis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Cadmium Ion Binding Protein Kinase Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway L-arginine Catabolic Process Regulation Of Systemic Arterial Blood Pressure Tachykinin Receptor Signaling Pathway Arginine Binding Regulation Of Blood Circulation Kinase Activity Plasma Membrane Membrane Vascular Process In Circulatory System Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin FMN Binding Circulatory System Process G Protein-coupled Receptor Binding Regulation Of Heart Contraction G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Biological Quality Regulation Of System Process Arginine Metabolic Process Negative Regulation Of Platelet Activation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Mediated Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Metalloendopeptidase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling
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