FAM25C and KLHL35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM25C	KLHL35
Description		family with sequence similarity 25 member C	kelch like family member 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function		Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process		Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Pancreas fat ( 34128465)
Interacting Genes		18 interacting genes: ARMC10 ARMCX3 COX16 GPD1 IGLL1 KLHL35 LCN1 LCN2 MIEF1 MIEF2 PPIC PPIF S100A6 SNX1 TDRKH TOMM20L TTPA ZFAND3	12 interacting genes: ACVR1 ALAS1 APPBP2 CALCOCO2 FAM25A FAM25C FAM25G GOLGA6L9 MX1 NCK2 TGFBR1 UBTD2
Entrez ID		644054	283212
HPRD ID		19638	08747
Ensembl ID		ENSG00000276430	ENSG00000149243
Uniprot IDs		B3EWG5	Q6PF15
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Outer Membrane Cyclosporin A Binding Regulation Of Mitochondrion Organization Mitochondrion Mitochondrion Organization Positive Regulation Of Mitochondrial Fission Mitochondrial Fusion Small Molecule Binding Positive Regulation Of Protein Targeting To Membrane Regulation Of Mitochondrial Fission Regulation Of Protein Targeting To Membrane Peptidyl-prolyl Cis-trans Isomerase Activity Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Establishment Of Blood-brain Barrier Regulation Of Proton-transporting ATPase Activity, Rotational Mechanism Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Positive Regulation Of Growth Rate TRNA Import Into Mitochondrion Cellular Response To Hydrogen Peroxide	Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Pharyngeal System Development Transforming Growth Factor Beta Binding Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding SMAD Binding Endocardial Cushion Cell Fate Commitment Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity 5-aminolevulinate Synthase Activity Response To Nickel Cation Vascular Endothelial Cell Proliferation Epicardium Morphogenesis
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