ZNF106 and MIRLET7I

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		ZNF106	MIRLET7I
Description		zinc finger protein 106	microRNA let-7i
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytosol Membrane Nuclear Speck	Extracellular Space Cytoplasm RISC Complex Extracellular Vesicle
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Insulin Receptor Signaling Pathway	Negative Regulation Of Gene Expression MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Defense Response To Protozoan
Pathways
Drugs
Diseases
GWAS		Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Triglyceride levels ( 32154731)
Interacting Genes		12 interacting genes: APC CREBBP EP300 MIR138-2 MIR21 MIR7-1 MIR93 MIRLET7I RNF10 SKIL UBE2I WNK1	113 interacting genes: AGO2 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CELF2 CHERP CPSF1 CRTAP CSTF1 CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EIF2AK2 ELAVL1 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 GRSF1 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 P3H1 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PUF60 PUM1 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM17 RBM4 RBM4B RBM5 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF106 ZNF346
Entrez ID		64397	406891
HPRD ID		10317
Ensembl ID		ENSG00000103994	ENSG00000199179
Uniprot IDs		A0A0C4DGM5 H3BSS6 Q9H2Y7
PDB IDs
Enriched GO Terms of Interacting Partners?		RISC Complex Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Histone H3K27 Acetyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Peptide Lactyltransferase (CoA-dependent) Activity Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Base-pairing Post-transcriptional Repressor Activity Extracellular Vesicle N-terminal Protein Amino Acid Acetylation Positive Regulation Of T-helper 17 Cell Differentiation Peptidyl-lysine Acetylation Post-transcriptional Regulation Of Gene Expression Regulation Of Cellular Response To Heat Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Acetyltransferase Activity Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of Cell Projection Organization Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway MRNA 3'-UTR Binding DNA Damage Response Histone Acetyltransferase Complex Regulation Of Primary Metabolic Process Protein-lysine-acetyltransferase Activity Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Cellular Response To Radiation Histone Acetyltransferase Activity Regulation Of Signal Transduction Regulation Of Protein Localization Protein Acetylation Regulation Of T-helper 17 Type Immune Response Regulation Of Cell Migration Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Signal Transduction	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of RNA Splicing Spliceosomal Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression Catalytic Step 2 Spliceosome MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process RNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MRNA Stabilization Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Protein-RNA Complex Assembly TRNA Aminoacylation Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process MiRNA Processing Nucleolus U2 SnRNP TRNA Metabolic Process Ligase Activity
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