MIRLET7I and PURA

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIRLET7I	PURA
Description		microRNA let-7i	purine rich element binding protein A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm RISC Complex Extracellular Vesicle	Chromosome, Telomeric Region Nucleus Cytoplasm Dendrite Neuronal Cell Body Postsynapse Glutamatergic Synapse
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	MRNA Regulatory Element Binding Translation Repressor Activity RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding Single-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Purine-rich Negative Regulatory Element Binding SMAD Binding DNA-binding Transcription Factor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Negative Regulation Of Gene Expression MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Defense Response To Protozoan	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Initiation Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Negative Regulation Of DNA-templated Transcription Lymphocyte Proliferation Epithelial Cell Proliferation Dendritic Transport Of Messenger Ribonucleoprotein Complex
Pathways
Drugs
Diseases
GWAS			Body mass index ( 26426971)
Interacting Genes		113 interacting genes: AGO2 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CELF2 CHERP CPSF1 CRTAP CSTF1 CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 DHX37 EIF2AK2 ELAVL1 EPRS1 ERAL1 ESRP1 FAM98A FIP1L1 FUS G3BP2 GRSF1 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 P3H1 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PUF60 PUM1 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM14 RBM17 RBM4 RBM4B RBM5 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR ZNF106 ZNF346	59 interacting genes: ADAP1 CCNT1 CDK5 E2F1 FILNC1 FOXP1 IL7R MIR1-1 MIR106B MIR122 MIR128-1 MIR128-2 MIR140 MIR143 MIR155 MIR15B MIR16-2 MIR17 MIR18B MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20B MIR21 MIR221 MIR222 MIR25 MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR7-1 MIR7-2 MIR9-2 MIR92A2 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT PTEN PURB RB1 SP1 YBX1
Entrez ID		406891	5813
HPRD ID			02721
Ensembl ID		ENSG00000199179	ENSG00000185129
Uniprot IDs			Q00577
PDB IDs			8CHT 8CHU 8CHV 8CHW
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Nucleus Regulation Of RNA Splicing Spliceosomal Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression Catalytic Step 2 Spliceosome MiRNA Binding Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Cytoplasmic Stress Granule Regulation Of Translation Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process RNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Catabolic Process MRNA Stabilization Regulation Of Gene Expression Negative Regulation Of Translation Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Protein-RNA Complex Assembly TRNA Aminoacylation Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process MiRNA Processing Nucleolus U2 SnRNP TRNA Metabolic Process Ligase Activity	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MRNA 3'-UTR Binding Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production MRNA Destabilization Negative Regulation Of Cell Motility RNA Destabilization Negative Regulation Of Locomotion Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Regulation Of Vasculature Development Regulation Of MRNA Stability Regulation Of Multicellular Organismal Development Regulation Of RNA Stability Positive Regulation Of MRNA Metabolic Process Regulation Of Cell Migration Extracellular Space Regulation Of Cell Motility Regulation Of Developmental Process Negative Regulation Of Protein Metabolic Process Regulation Of Locomotion Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Multicellular Organismal Process Regulation Of Endothelial Cell Migration Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
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