TMPPE and PLPPR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMPPE	PLPPR1
Description		transmembrane protein with metallophosphoesterase domain	phospholipid phosphatase related 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleoplasm Plasma Membrane Membrane Cell Projection Neuron Projection
	Molecular Function	Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Phosphatidate Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity
	Biological Process		Phospholipid Metabolic Process Signal Transduction Nervous System Development Phospholipid Dephosphorylation
Pathways			Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Hip circumference adjusted for BMI ( 28552196) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		35 interacting genes: AGTRAP ASGR2 CD79A CLDND2 CLRN1 CNR2 CYB561 FIS1 FXYD6 FXYD6-FXYD2 GPR152 IER3IP1 KCNJ6 KLRC1 LEMD1 MS4A1 PLLP PLPPR1 PNLIPRP1 REEP6 RETREG3 RTP2 SCN3B SFXN5 SLAMF6 SLC38A1 SMAGP SSMEM1 STX3 STX8 TMEM60 TMIE TRARG1 VAMP3 YIPF1	5 interacting genes: LEPROT PLN SERP1 SLC30A2 TMPPE
Entrez ID		643853	54886
HPRD ID		18951	17906
Ensembl ID		ENSG00000188167	ENSG00000148123
Uniprot IDs		Q6ZT21	Q8TBJ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Organelle Membrane Fusion SNAP Receptor Activity Vesicle Fusion SNARE Complex Organelle Fusion Membrane Fusion Vesicle Docking Endoplasmic Reticulum Organization Organelle Localization By Membrane Tethering External Side Of Plasma Membrane Membrane Docking	Response To Zinc Ion Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Response To Unfolded Protein Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Cellular Homeostasis Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Zinc Export Across Plasma Membrane Circadian Sleep/wake Cycle Process Vacuolar Transport Zinc Ion Import Into Lysosome ATPase Inhibitor Activity Zinc:proton Antiporter Activity Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Transporter Inhibitor Activity Regulation Of Relaxation Of Cardiac Muscle G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Sleep Vacuolar Transmembrane Transport Response To Endoplasmic Reticulum Stress Muscle Organ Morphogenesis Secretory Vesicle Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of ATP-dependent Activity Locomotor Rhythm Endoplasmic Reticulum Membrane Negative Regulation Of Heart Rate Endosome Membrane Zinc Ion Import Into Organelle Negative Regulation Of Protein Localization To Cell Surface Regulation Of Growth Hormone Receptor Signaling Pathway Relaxation Of Cardiac Muscle Regulation Of Growth Hormone Secretion Negative Regulation Of Calcium Ion Import Positive Regulation Of Establishment Of Protein Localization Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Response To Metal Ion Regulation Of Relaxation Of Muscle Zymogen Granule Membrane Monoatomic Cation Transmembrane Transporter Activity Relaxation Of Muscle Circadian Behavior
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