TMPPE and SFXN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMPPE	SFXN5
Description		transmembrane protein with metallophosphoesterase domain	sideroflexin 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Mitochondrion Mitochondrial Inner Membrane Membrane
	Molecular Function	Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Citrate Transmembrane Transporter Activity
	Biological Process		Monoatomic Ion Transport Amino Acid Transport Citrate Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Positive Regulation Of Cold-induced Thermogenesis Mitochondrial Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Asthma ( 31619474 31959851) Asthma (childhood onset) ( 31036433)	Breast milk fatty acid composition (maternal genotype effect) ( 29514873) Malaria ( 31844061) Non-word reading ( 30741946) Schizophrenia ( 30285260)
Interacting Genes		35 interacting genes: AGTRAP ASGR2 CD79A CLDND2 CLRN1 CNR2 CYB561 FIS1 FXYD6 FXYD6-FXYD2 GPR152 IER3IP1 KCNJ6 KLRC1 LEMD1 MS4A1 PLLP PLPPR1 PNLIPRP1 REEP6 RETREG3 RTP2 SCN3B SFXN5 SLAMF6 SLC38A1 SMAGP SSMEM1 STX3 STX8 TMEM60 TMIE TRARG1 VAMP3 YIPF1	9 interacting genes: APOL2 AQP6 CREB3L1 EBP ERGIC3 STOM TMEM237 TMEM86B TMPPE
Entrez ID		643853	94097
HPRD ID		18951	18047
Ensembl ID		ENSG00000188167	ENSG00000144040
Uniprot IDs		Q6ZT21	B4DIJ8 B8ZZJ6 Q8TD22
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Organelle Membrane Fusion SNAP Receptor Activity Vesicle Fusion SNARE Complex Organelle Fusion Membrane Fusion Vesicle Docking Endoplasmic Reticulum Organization Organelle Localization By Membrane Tethering External Side Of Plasma Membrane Membrane Docking	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Endoplasmic Reticulum C-8 Sterol Isomerase Activity Endoplasmic Reticulum Membrane Cholesterol-5,6-oxide Hydrolase Activity Cholestenol Delta-isomerase Activity Retrograde Transporter Complex, Golgi To ER D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Cholesterol Metabolic Process Steroid Delta-isomerase Activity Extracellular Matrix Constituent Secretion Sterol Metabolic Process Transporter Complex Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Cone Photoreceptor Outer Segment Monoatomic Anion Channel Activity Renal Water Transport Ammonium Channel Activity Ossification Involved In Bone Maturation Rod Photoreceptor Outer Segment
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