GPSM3 and PRR5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPSM3	PRR5
Description		G protein signaling modulator 3	proline rich 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Cytosol TORC2 Complex
	Molecular Function	Protein Binding GTPase Regulator Activity	Protein Binding
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Cytoskeleton Organization Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		G alpha (i) signalling events	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 31453325) Body mass index variance ( 31453325) Estimated glomerular filtration rate ( 31152163) Hip circumference ( 31453325) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Prostate cancer ( 23535732) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Binge eating behaviour in bipolar disorder ( 24882193 29391396) Electroencephalographic traits in alcoholism ( 22554406)
Interacting Genes		44 interacting genes: ACMSD ANKRD33 ASB15 BATF2 BMF C9orf57 CHRDL2 COA7 CTAG1A CTAG1B FAM86C1P FGFR3 GATAD2B GNAI1 GNAI2 GNAI3 HELT HIGD2B HRAS HSF2BP IQCE IVD KCNJ5-AS1 KRTAP11-1 KRTAP13-3 KRTAP19-4 MAPK7 MBD3L1 MEOX2 NR0B2 P4HA3 PRR5 RIPK4 RSPO4 SPAG8 SPMIP5 SPRY3 STXBP5L TADA2A TEX11 UFSP1 USHBP1 ZNF20 ZNF581	5 interacting genes: CTNNA3 DESI1 GPSM3 HGS USHBP1
Entrez ID		63940	55615
HPRD ID		13605	18696
Ensembl ID		ENSG00000213654	ENSG00000186654
Uniprot IDs		A0A024RCP6 Q9Y4H4	P85299
PDB IDs
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex	Chemoattraction Of Dopaminergic Neuron Axon Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Lobar Bronchus Development Trachea Cartilage Morphogenesis Renal Outer Medulla Development Outer Medullary Collecting Duct Development Bronchus Development Chemoattraction Of Axon Metanephric Loop Of Henle Development Inner Medullary Collecting Duct Development Renal Inner Medulla Development ESCRT-0 Complex
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