SDHB and SLC45A1

		SDHB	SLC45A1
Description		succinate dehydrogenase complex iron sulfur subunit B	solute carrier family 45 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex II (succinate Dehydrogenase)	Membrane
	Molecular Function	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Oxidoreductase Activity Metal Ion Binding Ubiquinone Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	D-glucose:proton Symporter Activity Sucrose:proton Symporter Activity Symporter Activity Galactose:proton Symporter Activity Transmembrane Transporter Activity
	Biological Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Mitochondrial Electron Transport, Succinate To Ubiquinone Aerobic Respiration Respiratory Electron Transport Chain Proton Motive Force-driven Mitochondrial ATP Synthesis	Galactose Transmembrane Transport Sucrose Transport Transmembrane Transport D-glucose Transmembrane Transport
Pathways		Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases
GWAS		A body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 20189936) Hip circumference adjusted for BMI ( 34021172) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)	Allergic rhinitis ( 30013184) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 23468962) Brown vs. black hair color ( 30531825) Depression ( 29700475) Fish- and plant-related diet ( 32066663) Hair color ( 29662168) Hair shape ( 29220522) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hippocampal volume in normal cognition ( 29274321) Inflammatory skin disease ( 25574825) Morning person ( 30696823) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Psoriasis ( 25903422 23143594) Schizophrenia ( 29483656 28991256) Strep throat ( 28928442) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		8 interacting genes: ABCA1 CARTPT GEM MSRA PIK3R5 SPRY2 TMEM132D XRN1	1 interacting genes: PPP1CA
Entrez ID		6390	50651
HPRD ID		01707	19078
Ensembl ID		ENSG00000117118	ENSG00000162426
Uniprot IDs		A0AAQ5BHD9 P21912	Q9Y2W3
PDB IDs		7KCL 7KCM 7KLU 7KLV 8GS8
Enriched GO Terms of Interacting Partners?		Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction	Cardiac Muscle Tissue Development Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Cytoplasmic Translational Initiation Cellular Response To Oxygen Levels Energy Reserve Metabolic Process Regulation Of Growth Regulation Of Circadian Rhythm TORC1 Complex Generation Of Precursor Metabolites And Energy Regulation Of Membrane Permeability Inositol Hexakisphosphate Binding Response To Temperature Stimulus RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding Cellular Response To Decreased Oxygen Levels Regulation Of Locomotor Rhythm Nucleobase-containing Small Molecule Metabolic Process Regulation Of Carbohydrate Catabolic Process Calcium-mediated Signaling Cellular Response To Hypoxia Energy Derivation By Oxidation Of Organic Compounds Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade TFIIIC-class Transcription Factor Complex Binding Regulation Of Pentose-phosphate Shunt RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Positive Regulation Of Cell Growth Striated Muscle Tissue Development Negative Regulation Of TORC2 Signaling Cellular Response To Insulin Stimulus Muscle Tissue Development Regulation Of Stress Fiber Assembly Positive Regulation Of Small Molecule Metabolic Process Regulation Of Calcium-mediated Signaling Cellular Response To Methionine Voluntary Musculoskeletal Movement 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Response To Insulin Small Molecule Metabolic Process Negative Regulation Of Lysosome Organization Regulation Of Translational Initiation Regulation Of Cell Growth T-helper 1 Cell Lineage Commitment RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of SCF-dependent Proteasomal Ubiquitin-dependent Catabolic Process Purine Ribonucleotide Biosynthetic Process Hormone Receptor Binding Ribose Phosphate Biosynthetic Process Regulation Of Blood Pressure
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?