SCN4B

Name	sodium voltage-gated channel beta subunit 4
Structure
Novel Interactors	1 novel interactors: SC5D
Interactors	2 interactors: SCN2A YIF1A
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Intercalated Disc Membrane
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Neuronal Action Potential Sodium Ion Transmembrane Transport Establishment Of Localization In Cell Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction
Pathways	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs	Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS	No GWAS studies recorded
Entrez ID	6330
HPRD ID	09749
Ensembl ID	ENSG00000177098
Uniprot IDs	B0YJ93 Q8IWT1
PDB IDs	4MZ2 4MZ3 5XAW 6VSV 7DTD
GO Terms Enriched among Interactors ?	Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Ferroptosis Negative Regulation Of Ferroptosis Voltage-gated Sodium Channel Complex Voltage-gated Sodium Channel Activity Node Of Ranvier Cholesterol Biosynthetic Process Sodium Channel Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Cation Channel Activity COPII-coated ER To Golgi Transport Vesicle Sterol Biosynthetic Process Cardiac Muscle Cell Action Potential