SCN4B

Description		sodium voltage-gated channel beta subunit 4
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Intercalated Disc Membrane
	Molecular Function	Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Transmembrane Transporter Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Neuronal Action Potential Sodium Ion Transmembrane Transport Establishment Of Localization In Cell Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS
Novel Interacting Genes		1 novel interacting genes: SC5D
Interacting Genes		2 interacting genes: SCN2A YIF1A
Entrez ID		6330
HPRD ID		09749
Ensembl ID		ENSG00000177098
Uniprot IDs		B0YJ93 Q8IWT1
PDB IDs		4MZ2 4MZ3 5XAW 6VSV 7DTD
Enriched GO Terms of Interacting Partners?		Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol C-5 Sterol Desaturase Activity Delta7-sterol 5(6)-desaturase Activity Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Ferroptosis Negative Regulation Of Ferroptosis Voltage-gated Sodium Channel Complex Voltage-gated Sodium Channel Activity Node Of Ranvier Cholesterol Biosynthetic Process Sodium Channel Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Monoatomic Cation Channel Activity COPII-coated ER To Golgi Transport Vesicle Sterol Biosynthetic Process Cardiac Muscle Cell Action Potential
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