SPOPL and KPNA5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SPOPL	KPNA5
Description		speckle type BTB/POZ protein like	karyopherin subunit alpha 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport
Pathways		Hedgehog 'on' state	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Response to antipsychotic treatment ( 23241943)	Early cardiac repolarization ( 31600170) Telomere length ( 21460395)
Interacting Genes		6 interacting genes: ATF2 CREB5 EPS15 KPNA5 MYD88 RXRB	29 interacting genes: ANP32A ANP32B ARNT ATM ATOSB BRMS1 CDKN1B CFTR DCPS EPAS1 FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326
Entrez ID		339745	3841
HPRD ID		11261	05179
Ensembl ID		ENSG00000144228	ENSG00000196911
Uniprot IDs		Q6IQ16	A0A8V8TL88 A0A8V8TMV2 O15131
PDB IDs			4U2X
Enriched GO Terms of Interacting Partners?		CAMP Response Element Binding Abducens Nucleus Development MRNA Transcription MRNA Transcription By RNA Polymerase II Hypoglossal Nucleus Development JNK Cascade Establishment Of Protein Localization To Organelle TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Protein Localization To Organelle Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Import Into Nucleus Sequence-specific Double-stranded DNA Binding H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of DNA-binding Transcription Factor Activity Growth Plate Cartilage Chondrocyte Proliferation DNA-binding Transcription Factor Activity Protein Import Into Nucleus RNA Polymerase II Transcription Regulator Complex Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Identical Protein Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Positive Regulation Of RNA Metabolic Process Response To Molecule Of Fungal Origin Ubiquitin-dependent Endocytosis Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Toll-like Receptor Binding Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Brainstem Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis	Nucleoplasm Nucleus Negative Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Catabolic Process Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Multicellular Organismal Process DNA Double-strand Break Processing Embryonic Placenta Development Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Apoptotic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Chromatin Negative Regulation Of Double-strand Break Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Repair MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Histone Deacetylase Binding Regulation Of Protein Modification Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Negative Regulation Of DNA Recombination Positive Regulation Of Hormone Biosynthetic Process DNA-binding Transcription Factor Activity
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