RPS6KA2 and TBXT

		RPS6KA2	TBXT
Description		ribosomal protein S6 kinase A2	T-box transcription factor T
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Synapse Meiotic Spindle	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Oocyte Maturation Brain Renin-angiotensin System Signal Transduction Chemical Synaptic Transmission Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Somitogenesis Heart Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Mesoderm Development Anterior/posterior Axis Specification, Embryo Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Myoblast Differentiation Primitive Streak Formation
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK	Cardiogenesis Germ layer formation at gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Formation of definitive endoderm
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756 34002096) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) Café-au-lait macule number in neurofibromatosis type1 ( 32869517) Dental caries ( 23259602) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 23128233 27569725) Macrovascular complications in type 2 diabetes ( 33430853) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)
Interacting Genes		12 interacting genes: BAD CREB1 FLNC FOS JUN L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 SHANK1 TP53	3 interacting genes: NFIA NFIB NFIC
Entrez ID		6196	6862
HPRD ID		03403	03236
Ensembl ID		ENSG00000071242	ENSG00000164458
Uniprot IDs		B7Z3B5 F2Z2J1 Q15349 X5D337	J3KP65 O15178
PDB IDs			5QRF 5QRG 5QRH 5QRI 5QRJ 5QRK 5QRL 5QRM 5QRN 5QRO 5QRP 5QRQ 5QRR 5QRS 5QRT 5QRU 5QRV 5QRW 5QRX 5QRY 5QRZ 5QS0 5QS1 5QS2 5QS3 5QS4 5QS5 5QS6 5QS7 5QS8 5QS9 5QSA 5QSB 5QSC 5QSD 5QSE 5QSF 5QSG 5QSH 5QSI 5QSJ 5QSK 5QSL 5QT0 6F58 6F59 6ZU8 7HI8 7HI9 7ZK2 7ZKF 7ZL2 8A10 8A7N 8CDN 8FMU
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Face Development Schwann Cell Development Animal Organ Formation ERBB2 Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Lung Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Regulation Of Stress-activated MAPK Cascade Cell Differentiation Gland Development Anatomical Structure Morphogenesis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cellular Component Organization Response To Lipid Cell Surface Receptor Signaling Pathway Response To Nicotine Transcription Factor AP-1 Complex Regulation Of Cell Development Thymus Development Intracellular Signaling Cassette Cardiac Neural Crest Cell Development Involved In Heart Development Response To Epidermal Growth Factor ERK1 And ERK2 Cascade Positive Regulation Of MiRNA Transcription Outer Ear Morphogenesis Identical Protein Binding Cellular Response To Starvation Positive Regulation Of MiRNA Metabolic Process Glial Cell Development Response To Mechanical Stimulus	Glial Cell Fate Specification DNA Replication Exit From Mitosis Generation Of Neurons Neuron Fate Specification Glial Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Retina Development In Camera-type Eye Cell Fate Specification DNA-binding Transcription Factor Activity Neural Precursor Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Neurogenesis DNA Metabolic Process Double-stranded DNA Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Involved In Salivary Gland Development Fibrillar Center Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Brain Renin-angiotensin System Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Principal Sensory Nucleus Of Trigeminal Nerve Development Developmental Maturation Chromatin Response To Wounding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Club Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Salivary Gland Cavitation Anterior Commissure Morphogenesis Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Transcription By RNA Polymerase II Ureter Development Positive Regulation Of Metabolic Process Gene Expression Multi-ciliated Epithelial Cell Differentiation Type II Pneumocyte Differentiation Cerebellar Mossy Fiber Negative Regulation Of Mesenchymal Cell Proliferation Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Animal Organ Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Type I Pneumocyte Differentiation Negative Regulation Of Meiotic Nuclear Division Macromolecule Biosynthetic Process
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