ATG101 and ATG13

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay)

		ATG101	ATG13
Description		autophagy related 101	autophagy related 13
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GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Endoplasmic Reticulum Membrane Cytosol Atg1/ULK1 Kinase Complex	Phagophore Assembly Site Cytoplasm Mitochondrion Autophagosome Endoplasmic Reticulum Membrane Cytosol Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Autophagosome Assembly Autophagy Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy	Autophagosome Assembly Mitophagy Autophagy Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Regulation Of Cell Population Proliferation Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Macroautophagy	Macroautophagy
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)
Interacting Genes		6 interacting genes: ATG13 ATG4A CSNK2B GABARAP MYL3 PTCH1	13 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C OTOS RNF31 SMCR8 ULK1
Entrez ID		60673	9776
HPRD ID		08566	13809
Ensembl ID		ENSG00000123395	ENSG00000175224
Uniprot IDs		Q9BSB4	A8K0S6 O75143
PDB IDs		4WZG 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 8DO8	3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN 8DO8 8SOI 8SQZ 8SRM 9C82
Enriched GO Terms of Interacting Partners?		Mitophagy Autophagy Of Mitochondrion Autophagosome Organization Autophagosome Assembly Protein Kinase Regulator Activity Macroautophagy Piecemeal Microautophagy Of The Nucleus Vacuole Organization Microautophagy Nucleophagy Autophagy Tissue Morphogenesis Neural Plate Axis Specification Autophagosome Epithelial Tube Morphogenesis Myosin II Heavy Chain Binding Response To Chlorate Negative Regulation Of Cell Population Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Muscle Tissue Development Intracellular Protein Localization Epidermal Cell Fate Specification Smoothened Binding Hedgehog Family Protein Binding Hedgehog Receptor Activity Organelle Assembly Positive Regulation Of Protein K48-linked Ubiquitination Protein-phosphatidylethanolamide Deconjugating Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Processing Release From Viral Latency Protein Delipidation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Viral Life Cycle Response To Mitochondrial Depolarisation Regulation Of Protein K48-linked Ubiquitination Adiponectin-activated Signaling Pathway Patched Binding Cell Proliferation Involved In Metanephros Development Mammary Gland Duct Morphogenesis Neural Tube Patterning Dendritic Growth Cone Regulation Of Protein Localization Atg1/ULK1 Kinase Complex Neural Tube Formation Metanephric Collecting Duct Development Cell Proliferation Involved In Kidney Development	Mitophagy Autophagosome Membrane Autophagosome Organization Autophagosome Assembly Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Autophagosome Autophagy Vacuole Organization Autophagosome Maturation Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Protein-containing Complex Disassembly Cellular Response To Starvation Phospholipid Binding Organelle Assembly Response To Nutrient Levels Ubiquitin Protein Ligase Binding Atg1/ULK1 Kinase Complex Cytoplasmic Vesicle Catabolic Process Protein-containing Complex Organization GABA Receptor Binding Cellular Component Assembly Phagophore Assembly Site Positive Regulation Of Catabolic Process Microtubule Beta-tubulin Binding Cellular Response To Stress Organelle Membrane Regulation Of Autophagy Response To Stress Positive Regulation Of Autophagy Regulation Of Macroautophagy Organelle Organization Microtubule Binding Endomembrane System Positive Regulation Of Macroautophagy Response To Lead Ion Axoneme Cytosol Phagophore Assembly Site Membrane Cellular Response To Copper Ion Cytoplasm Response To Copper Ion GTPase Binding Regulation Of Autophagosome Assembly Amyloid-beta Complex
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