HIST3H2BB

Gene Name		histone cluster 3, H2bb
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm
	Molecular Function	Molecular_function DNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-protein Interactions		5 interactors: BRD2 CBX5 CDKN2A RPS6KA5 USP7
Entrez ID		128312
HPRD ID		13661
Ensembl ID		ENSG00000196890
Uniprot IDs		Q8N257
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Chromosome Organization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Transcription, DNA-templated Histone H2A-S1 Phosphorylation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Chromatin Assembly Regulation Of Gene Expression Chromatin Assembly Or Disassembly Regulation Of Nitrogen Compound Metabolic Process DNA Packaging Senescence-associated Heterochromatin Focus Assembly Histone H3-S10 Phosphorylation Positive Regulation Of Cellular Senescence Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Conformation Change Negative Regulation Of Immature T Cell Proliferation In Thymus Organelle Organization Positive Regulation Of Macrophage Apoptotic Process Maintenance Of DNA Methylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic DNA Fragmentation Histone H3-S28 Phosphorylation Positive Regulation Of Cell Aging Response To Stress Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Cellular Response To Stress Heterochromatin Assembly Histone Modification Positive Regulation Of Protein Sumoylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Smooth Muscle Cell Apoptotic Process Heterochromatin Organization Regulation Of Metabolic Process Regulation Of Macrophage Apoptotic Process Replicative Senescence Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of B Cell Proliferation Interleukin-1-mediated Signaling Pathway
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