RBP3 and POU4F2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RBP3	POU4F2
Description		retinol binding protein 3	POU class 4 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Interphotoreceptor Matrix Cone Matrix Sheath Extracellular Vesicle	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck
	Molecular Function	Retinoid Binding Protein Binding Serine-type Peptidase Activity Retinal Binding Retinol Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Visual Perception	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Axon Guidance Heart Development Sensory Perception Of Sound Cell Differentiation Neuron Differentiation Estrogen Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Cellular Response To Insulin Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Axon Extension Neuromuscular Process Controlling Balance Regulation Of DNA-binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		The retinoid cycle in cones (daylight vision) The canonical retinoid cycle in rods (twilight vision)	Regulation of TP53 Activity through Association with Co-factors
Drugs		Lapachone
Diseases
GWAS		Corneal curvature ( 24963161) Macular thickness ( 30535121)	Malaria ( 31844061) Metabolite levels ( 23823483)
Interacting Genes		15 interacting genes: CDC23 CREB5 CYSRT1 EFEMP2 HOXA1 HR HSD3B7 KPRP KRTAP10-5 MGAT5B NID2 NOTCH1 PLSCR4 POU4F2 SPAG8	77 interacting genes: ADAMTSL4 ALPP CCN3 CD46 CERCAM CHIC2 CHRD CHRDL2 COL8A1 CYP21A2 CYSRT1 DLX3 ESR1 FAM86C1P GRN HDHD3 HIGD2B IGFBP6 IGFL1 INCA1 KPRP KRT31 KRT35 KRT38 KRT83 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE1F LCE2C LCE5A LCN2 LGALS13 LHX2 LYPD2 MMADHC NFKBID NOTO PCSK5 PLSCR2 RBP3 RBPMS RGS19 SPRY4 TGFB1 TRIM42 VWC2
Entrez ID		5949	5458
HPRD ID		01581	00220
Ensembl ID		ENSG00000265203	ENSG00000151615
Uniprot IDs		P10745	Q12837
PDB IDs
Enriched GO Terms of Interacting Partners?		Artery Development Semicircular Canal Formation Artery Morphogenesis Abducens Nerve Formation Optokinetic Behavior MAML1-RBP-Jkappa- ICN1 Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Vascular Associated Smooth Muscle Cell Development Regulation Of Extracellular Matrix Organization Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Vasculogenesis Involved In Coronary Vascular Morphogenesis Venous Endothelial Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Distal Tubule Development Muscle Tissue Morphogenesis Regulation Of Smooth Muscle Cell Differentiation Epidermis Development Auditory Receptor Cell Fate Commitment Notch Signaling Involved In Heart Development Positive Regulation Of Muscle Cell Differentiation Regulation Of Aorta Morphogenesis Growth Involved In Heart Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Muscle Cell Development Chromatin DNA Binding Epidermal Cell Fate Specification Endocardium Morphogenesis Coronary Sinus Valve Morphogenesis Retinal Cone Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Pro-B Cell Differentiation Negative Regulation Of Neuron Differentiation Calcium Ion Binding Cardiac Right Ventricle Formation Glomerular Mesangial Cell Development Cell Migration Involved In Endocardial Cushion Formation Chemical Synaptic Transmission, Postsynaptic Foregut Morphogenesis Compartment Pattern Specification Mitral Valve Formation Arterial Endothelial Cell Differentiation Cellular Response To Tumor Cell Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Smooth Muscle Cell Differentiation Tissue Development Cardiac Vascular Smooth Muscle Cell Development Negative Regulation Of Extracellular Matrix Constituent Secretion Epithelium Development Positive Regulation Of Aorta Morphogenesis	Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Keratinization Protein Binding Cytosol Structural Constituent Of Skin Epidermis Identical Protein Binding
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