RXFP1 and RLN2

Number of citations of the paper that reports this interaction (PMID 12506116)
29

Data Source:
HPRD (in vitro)

		RXFP1	RLN2
Gene Name		relaxin/insulin-like family peptide receptor 1	relaxin 2
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Metal Ion Binding	Hormone Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway	Female Pregnancy
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Relaxin receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: RLN1 RLN2 RLN3	2 interactors: RXFP1 RXFP2
Entrez ID		59350	6019
HPRD ID		05975	01561
Ensembl ID		ENSG00000171509	ENSG00000107014
Uniprot IDs		B3KV27 B4DGP2 Q59H16 Q9HBX9	P04090
PDB IDs		2JM4 2M7P	6RLX
Enriched GO Terms of Interacting Partners?		Female Pregnancy Reproductive Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Parturition Oocyte Maturation G-protein Coupled Receptor Signaling Pathway Reproductive Process Oocyte Development Oocyte Differentiation Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Oogenesis Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Female Gamete Generation Cell Maturation Male Gonad Development Mammary Gland Development Male Sex Differentiation Organ Development Cell Surface Receptor Signaling Pathway Gonad Development Development Of Primary Sexual Characteristics Connective Tissue Development Cell Differentiation Lung Development Germ Cell Development Respiratory Tube Development Respiratory System Development Sex Differentiation
Tagcloud ?		bioactive birth boars borne esr1 fed gata insl3 lactocrine leydig libitum neonatal nursed p450 p450scc pan pnd porcine proliferating reflected relaxin replacer sertoli steroidogenic testes testicular vegfa whereby
Tagcloud (Difference) ?		bioactive birth boars borne esr1 fed gata insl3 lactocrine leydig libitum neonatal nursed p450 p450scc pan pnd porcine proliferating reflected relaxin replacer sertoli steroidogenic testes testicular vegfa whereby
Tagcloud (Intersection) ?