UBL5 and PSME2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBL5	PSME2
Description		ubiquitin like 5	proteasome activator subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cajal Body	Proteasome Complex Nucleoplasm Cytoplasm Cytosol Proteasome Activator Complex Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein Tag Activity	Protein Binding Identical Protein Binding Endopeptidase Activator Activity
	Biological Process	MRNA Splicing, Via Spliceosome Protein Modification Process Positive Regulation Of Protein Targeting To Mitochondrion	Regulation Of Proteasomal Protein Catabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		mRNA Splicing - Major Pathway	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs
Diseases
GWAS		Sleep duration ( 30531941) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Suicide behavior ( 26079190)
Interacting Genes		49 interacting genes: BEND7 BIN3 C1QTNF1 CCDC196 CCDC28B CERCAM CLK1 CLK2 CLK4 CTAG1A CTAG1B DMRTB1 FAM50B FANCI GCSAML HESX1 HID1 HMGXB4 HOXA1 HSPB2 KRTAP10-8 KRTAP13-3 LENG1 MBD3L1 NCOA5 NFYA NME4 NRIP3 PAX4 PHACTR3 PINX1 PRMT8 PSME2 SART1 SEPTIN2 SERTAD3 SF1 SMCP SPANXB1 SPATC1L TEX35 THAP3 TLE5 TRIM27 TRIM39 WASHC1 ZFP41 ZNF124 ZNF618	10 interacting genes: APP CEBPA DUSP23 EPHA2 LNX1 MYOD1 NAA10 NHLH1 PSME1 UBL5
Entrez ID		59286	5721
HPRD ID		06028	03697
Ensembl ID		ENSG00000198258	ENSG00000100911
Uniprot IDs		A0A024R7B0 Q9BZL1	Q86SZ7 Q9UL46
PDB IDs		1P0R 4PYU 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9	7DR6 7DRW 7NAO 7NAP 8CXB
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Serine/threonine/tyrosine Kinase Activity	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Chemokine Production Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Protein Catabolic Process Cell Development Molecular Function Activator Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Chromatin DNA Binding CHOP-C/EBP Complex Cellular Response To Tumor Necrosis Factor RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Vitamin B2 C/EBP Complex Negative Regulation Of Lymphangiogenesis Notochord Cell Development Notochord Formation Axial Mesoderm Formation Myoblast Fate Determination Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Proteasome Activator Complex Protein-N-terminal-alanine Acetyltransferase Activity Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Protein N-terminal-serine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway System Development Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Defense Response To Gram-positive Bacterium
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