RANBP1 and PRODH

		RANBP1	PRODH
Description		RAN binding protein 1	proline dehydrogenase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Centrosome Cytosol	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Cadherin Binding	Proline Dehydrogenase Activity Oxidoreductase Activity FAD Binding
	Biological Process	Nucleocytoplasmic Transport Signal Transduction Positive Regulation Of Mitotic Centrosome Separation	Proline Metabolic Process L-proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress L-proline Catabolic Process To L-glutamate Trans-4-hydroxy-L-proline Catabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways		Rev-mediated nuclear export of HIV RNA	Proline catabolism
Drugs		Copper Phenethyl Isothiocyanate	Proline
Diseases			Hyperprolinemia (HP)
GWAS			Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235 33031748) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CD93 CEBPA MDM2 NUPR1 RAN RANGRF RCC1
Entrez ID		5902	5625
HPRD ID		03110	08433
Ensembl ID		ENSG00000099901	ENSG00000100033
Uniprot IDs		A0A140VK94 B3KUP2 B4DE76 F6WQW2 P43487	E7EQL6 O43272
PDB IDs		1K5D 1K5G
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Spindle Organization Chromatin Binding Spindle Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Domain Specific Binding Nucleoplasm Protein-containing Complex Acute Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Heterodimerization Activity Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Protein Catabolic Process Response To Vitamin Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Response To Vitamin B2 Regulation Of Cell Cycle C/EBP Complex Microtubule Cytoskeleton Organization Spindle Assembly Positive Regulation Of Intracellular Protein Transport Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization Signal Transduction By P53 Class Mediator Response To Toxic Substance Proline Dehydrogenase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Heart Rate Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Vitamin B1 Regulation Of Cellular Localization Response To Water-immersion Restraint Stress Regulation Of Nucleocytoplasmic Transport Cellular Response To Actinomycin D L-proline Catabolic Process To L-glutamate Negative Regulation Of Type B Pancreatic Cell Proliferation	Social Behavior
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