ALS2 and PPIL3

		ALS2	PPIL3
Description		alsin Rho guanine nucleotide exchange factor ALS2	peptidylprolyl isomerase like 3
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Early Endosome Centrosome Cytosol Postsynaptic Density Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex Dendritic Spine Intracellular Membrane-bounded Organelle Glutamatergic Synapse	Nucleoplasm Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity
	Biological Process	Behavioral Fear Response Receptor Recycling Response To Oxidative Stress Endosome Organization Lysosomal Transport Neuromuscular Junction Development Locomotory Behavior Intracellular Protein Localization Vesicle Organization Endosomal Transport Positive Regulation Of Rac Protein Signal Transduction Synaptic Transmission, Glutamatergic Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Regulation Of Biological Quality Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing
Pathways		RAB GEFs exchange GTP for GDP on RABs RAC1 GTPase cycle	mRNA Splicing - Major Pathway
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		1 interacting genes: YWHAB	10 interacting genes: CENATAC DMRTB1 PCBP1 PHC1 RPS13 SHARPIN SLU7 TAB2 TAB3 YTHDF1
Entrez ID		57679	53938
HPRD ID		05893	15163
Ensembl ID		ENSG00000003393	ENSG00000240344
Uniprot IDs		A0A7P0T8F3 A0A7P0Z4I4 A8K4R4 Q96Q42	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs			1XYH 2OJU 2OK3 8C6J
Enriched GO Terms of Interacting Partners?		IMP Dehydrogenase Activity Nuclear Migration Along Microfilament Nuclear Migration Along Microtubule Nuclear Matrix Organization Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Nuclear Matrix Anchoring At Nuclear Membrane GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process Phosphoserine Residue Binding Cytoskeleton-nuclear Membrane Anchor Activity Meiotic Nuclear Membrane Microtubule Tethering Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?