CC2D2A and NCAPG

Data Source: HiPPIP (Novel)

		CC2D2A	NCAPG
Name		coiled-coil and C2 domain containing 2A	non-SMC condensin I complex subunit G
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Ciliary Transition Zone MKS Complex Cell Projection	Condensed Chromosome, Centromeric Region Condensed Chromosome Condensed Nuclear Chromosome Condensin Complex Nucleus Chromosome Cytoplasm Cytosol Membrane
	Molecular Function	None	Protein Binding
	Biological Process	Kidney Development Neural Tube Closure Smoothened Signaling Pathway Determination Of Left/right Symmetry Heart Development Cell Projection Organization Axoneme Assembly Camera-type Eye Development Motile Cilium Assembly Cilium Assembly Protein Localization To Ciliary Transition Zone Non-motile Cilium Assembly Embryonic Brain Development	Mitotic Chromosome Condensation Chromosome Condensation Cell Division Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Positive Regulation Of Chromosome Condensation
Pathways		Anchoring of the basal body to the plasma membrane	Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Diseases		Joubert syndrome Meckel syndrome (MKS); Meckel-Gruber syndrome COACH syndrome	None
GWAS		General risk tolerance (MTAG) ( 30643258 ) Initial pursuit acceleration ( 29064472 ) Joint mobility (Beighton score) ( 27182965 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 29403010 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Obesity-related traits ( 23251661 ) Red blood cell count ( 27863252 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Height ( 18391951 20189936 25429064 34270706 ) Hip circumference adjusted for BMI ( 34021172 ) Lung volume ( 34128465 ) Metabolite levels ( 23823483 )
Novel Interactors		3 novel interactors: CPEB2 NCAPG RAB28	1 novel interactors: CC2D2A
Interacting Genes		1 interacting genes: CEP290	4 interacting genes: CDK1 DNMT3B HSF2 SUMO2
Entrez ID		57545	64151
HPRD ID		11141	12097
Ensembl ID		ENSG00000048342	ENSG00000109805
Uniprot IDs		H0Y941 Q9P2K1	Q9BPX3
PDB IDs		Not available	6IGX
GO Terms Enriched among Interactors		Ciliary Rootlet Ciliary Basal Body Condensin Complex Positive Regulation Of Chromosome Condensation Pronephros Development Otic Vesicle Formation Ciliary Transition Zone Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Cytoplasmic Translation Negative Regulation Of Translational Elongation Negative Regulation Of Cytoplasmic Translational Elongation Regulation Of Chromosome Condensation MKS Complex Microtubule Minus-end Binding GTPase Inhibitor Activity Ribosomal Large Subunit Binding Regulation Of Translational Elongation Condensed Chromosome, Centromeric Region Mitotic Chromosome Condensation MRNA Regulatory Element Binding Translation Repressor Activity Translation Regulator Activity Hindbrain Development Ribosomal Small Subunit Binding Translation Factor Activity, RNA Binding	Pronuclear Fusion Mitotic DNA-templated DNA Replication Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Cyclin-dependent Protein Kinase Activity DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Thymidine Metabolic Process Golgi Disassembly Regulation Of Schwann Cell Differentiation Regulation Of Transcription By RNA Polymerase II Nuclear DNA Replication Thymidine Biosynthetic Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone Kinase Activity Protein Localization To Ciliary Transition Zone Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cilium Organization Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Cilium Disassembly Pyrimidine Nucleoside Metabolic Process Protein Localization To Kinetochore MKS Complex Regulation Of Metaphase Plate Congression DNA Strand Resection Involved In Replication Fork Processing Nuclear Membrane Disassembly Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Membrane Disassembly SUMO Transferase Activity Embryonic Brain Development Regulation Of RNA Metabolic Process Nuclear Envelope Organization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Peptidyl-threonine Phosphorylation Microtubule Cytoskeleton Organization Microtubule Polymerization Catalytic Complex