CC2D2A and RAB28

		CC2D2A	RAB28
Description		coiled-coil and C2 domain containing 2A	RAB28, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Ciliary Transition Zone MKS Complex Cell Projection	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Endomembrane System Membrane Ciliary Rootlet Ciliary Basal Body Cell Projection
	Molecular Function		Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Kidney Development Neural Tube Closure Smoothened Signaling Pathway Determination Of Left/right Symmetry Heart Development Cell Projection Organization Axoneme Assembly Camera-type Eye Development Motile Cilium Assembly Cilium Assembly Protein Localization To Ciliary Transition Zone Non-motile Cilium Assembly Embryonic Brain Development	Intracellular Protein Transport
Pathways		Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Joubert syndrome Meckel syndrome (MKS); Meckel-Gruber syndrome COACH syndrome
GWAS		General risk tolerance (MTAG) ( 30643258) Initial pursuit acceleration ( 29064472) Joint mobility (Beighton score) ( 27182965) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Red blood cell count ( 27863252)	Heel bone mineral density ( 30598549) Height ( 25282103 31562340) Obesity-related traits ( 23251661) Periodontal disease-related phenotype (Socransky) ( 24347629) Photic sneeze reflex ( 30899065)
Interacting Genes		1 interacting genes: CEP290	3 interacting genes: ACSF3 APP PLEKHF2
Entrez ID		57545	9364
HPRD ID		11141	06699
Ensembl ID		ENSG00000048342	ENSG00000157869
Uniprot IDs		H0Y941 Q9P2K1	P51157
PDB IDs			2HXS 3E5H
Enriched GO Terms of Interacting Partners?		Ciliary Rootlet Ciliary Basal Body Condensin Complex Positive Regulation Of Chromosome Condensation Pronephros Development Otic Vesicle Formation Ciliary Transition Zone Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Cytoplasmic Translation Negative Regulation Of Translational Elongation Negative Regulation Of Cytoplasmic Translational Elongation Regulation Of Chromosome Condensation MKS Complex Microtubule Minus-end Binding GTPase Inhibitor Activity Ribosomal Large Subunit Binding Regulation Of Translational Elongation Condensed Chromosome, Centromeric Region Mitotic Chromosome Condensation MRNA Regulatory Element Binding Translation Repressor Activity Translation Regulator Activity Hindbrain Development Ribosomal Small Subunit Binding Translation Factor Activity, RNA Binding	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Malonyl-CoA Synthetase Activity Malonate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Early Endosome Membrane Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Protein Localization To Ciliary Transition Zone CoA-ligase Activity Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Early Endosome Cellular Response To Manganese Ion Very Long-chain Fatty Acid-CoA Ligase Activity Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding
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