ARID1B and MTHFD1L

		ARID1B	MTHFD1L
Description		AT-rich interaction domain 1B	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane SWI/SNF Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Mitochondrion Mitochondrial Matrix Cytosol Membrane
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding Nucleosome Binding	Nucleotide Binding Formate-tetrahydrofolate Ligase Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity ATP Binding Ligase Activity Protein Homodimerization Activity
	Biological Process	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Neural Tube Closure One-carbon Metabolic Process Folic Acid-containing Compound Metabolic Process 10-formyltetrahydrofolate Biosynthetic Process Formate Metabolic Process Formate Biosynthetic Process Tetrahydrofolate Interconversion Carboxylic Acid Biosynthetic Process Tetrahydrofolate Metabolic Process Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Metabolism of folate and pterines
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease biomarkers ( 23419831) Calcium levels ( 24068962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Iris color (b* coordinate) ( 30895295) Lipoprotein (a) levels ( 26377243) Low density lipoprotein cholesterol levels ( 30498476) Multiple system atrophy (pathologically confirmed) ( 27629089) Pancreatic cancer ( 22158540) Psychosis proneness (perceptual aberration scale and revised physical anhedonia scale) ( 28525603) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Type 2 diabetes ( 29621232) Vein graft stenosis in coronary artery bypass grafting ( 25881214) Western dietary pattern ( 28644415)	Alzheimer's disease (late onset) ( 20885792) Chronic myeloid leukemia ( 21540461) Coronary heart disease ( 17634449) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Type 2 diabetes ( 25760438)
Interacting Genes		7 interacting genes: CUL2 ENO1 H2BC21 PYGM SMAD9 SMARCA2 SMARCA4	2 interacting genes: FILNC1 HGS
Entrez ID		57492	25902
HPRD ID		10660	09967
Ensembl ID		ENSG00000049618	ENSG00000120254
Uniprot IDs		A0A1B0GTJ8 A0A1B0GVK1 A0A3F2YNW7 A0A6Q8NVI4 H0Y7H8 Q8NFD5	A0A087WVM4 B2RD24 B7ZM99 Q6UB35
PDB IDs		2CXY 2EH9
Enriched GO Terms of Interacting Partners?		Nucleosome Array Spacer Activity BBAF Complex NpBAF Complex GBAF Complex NBAF Complex Regulation Of Nucleotide-excision Repair SWI/SNF Complex ATP-dependent Activity, Acting On DNA Negative Regulation Of Cell Growth Regulation Of G0 To G1 Transition Negative Regulation Of Growth Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Myoblast Differentiation Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Regulation Of Stem Cell Population Maintenance Transcription Coactivator Activity Cohesin Loader Activity Scc2-Scc4 Cohesin Loading Complex SMC Loading Complex 10-formyltetrahydrofolate Biosynthetic Process Formate-tetrahydrofolate Ligase Activity Fructose-1-phosphatase Activity Regulation Of Myoblast Differentiation Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Nucleoplasm Glycogen Phosphorylase Activity Positive Regulation Of Glucose Mediated Signaling Pathway Formate Biosynthetic Process
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