SLC12A5 and DBNDD2

		SLC12A5	DBNDD2
Description		solute carrier family 12 member 5	dysbindin domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Dendrite Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Periphery Glutamatergic Synapse Postsynaptic Specialization Membrane	Cytoplasm Lysosome Endoplasmic Reticulum
	Molecular Function	Ammonium Channel Activity Chloride Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Metal Ion Binding	Protein Binding ATPase Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Chloride Transport Cell Volume Homeostasis Hypotonic Response Chemical Synaptic Transmission Learning Response To Xenobiotic Stimulus Intracellular Chloride Ion Homeostasis Developmental Process Multicellular Organism Growth Thermosensory Behavior Intracellular PH Reduction Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Dendritic Spine Development Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Postsynaptic Neurotransmitter Receptor Diffusion Trapping Regulation Of Postsynapse Assembly Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Negative Regulation Of Protein Kinase Activity Apoptotic Process Regulation Of Signal Transduction Neurogenesis Neuron Projection Development Monoatomic Ion Homeostasis ERK1 And ERK2 Cascade
Pathways		Cation-coupled Chloride cotransporters
Drugs		Potassium chloride Bumetanide
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 32888494) Systemic sclerosis ( 29293537) Triglyceride levels ( 32154731)	Malaria ( 31844061)
Interacting Genes		2 interacting genes: CCR4 F2RL1	7 interacting genes: AGTR1 CALCOCO2 CSNK1G2 CSNK1G3 LMNA SFRP2 VIPR2
Entrez ID		57468	55861
HPRD ID		09469	12763
Ensembl ID		ENSG00000124140	ENSG00000244274
Uniprot IDs		Q9H2X9	Q9BQY9
PDB IDs		6M23 7D8Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Phosphatidylinositol-3,5-bisphosphate Binding Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Histone H1 Reader Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Chromatin Lock Complex SAM Domain Binding UDP-glucose Transmembrane Transport Calcium-mediated Signaling Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Mature Conventional Dendritic Cell Differentiation Regulation Of Neutrophil Mediated Cytotoxicity Negative Regulation Of Macromolecule Metabolic Process Regulation Of System Process Positive Regulation Of Killing Of Cells Of Another Organism Thrombin-activated Receptor Activity Regulation Of Muscle Contraction Z Disc Histone H4K20me2 Reader Activity Protein O-linked Glycosylation Via Fucose Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Junctional Membrane Complex Regulation Of Cardiac Muscle Tissue Development	Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Angiotensin Type I Receptor Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Dermatome Development Thermosensory Behavior Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production DNA Double-strand Break Attachment To Nuclear Envelope Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Structural Constituent Of Nuclear Lamina Sclerotome Development Wnt Signaling Pathway Involved In Somitogenesis Negative Regulation Of Embryonic Development Negative Regulation Of Mesodermal Cell Fate Specification Regulation Of Midbrain Dopaminergic Neuron Differentiation Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Regulation Of Cellular Component Organization Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Import Into Cell Regulation Of Extrinsic Apoptotic Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Cell-cell Signaling Stem Cell Fate Specification Development Of Primary Male Sexual Characteristics Signaling Convergent Extension Involved In Axis Elongation Cell Communication Potassium:chloride Symporter Activity Regulation Of Renal Sodium Excretion Negative Regulation Of Mesenchymal Cell Proliferation Mesodermal Cell Fate Specification Regulation Of Establishment Of Planar Polarity Xenophagy Positive Regulation Of Autophagosome Maturation Postsynaptic Neurotransmitter Receptor Diffusion Trapping Receptor Diffusion Trapping Regulation Of Mesodermal Cell Differentiation Development Of Primary Sexual Characteristics Ammonium Channel Activity Chloride:monoatomic Cation Symporter Activity Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Negative Regulation Of Apoptotic Signaling Pathway
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