SLC12A5 and SLC35H1

		SLC12A5	SLC35H1
Description		solute carrier family 12 member 5	solute carrier family 35 member H1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Dendrite Membrane Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Cell Periphery Glutamatergic Synapse Postsynaptic Specialization Membrane	Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Ammonium Channel Activity Chloride Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Metal Ion Binding	Protein Binding Antiporter Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Chloride Transport Cell Volume Homeostasis Hypotonic Response Chemical Synaptic Transmission Learning Response To Xenobiotic Stimulus Intracellular Chloride Ion Homeostasis Developmental Process Multicellular Organism Growth Thermosensory Behavior Intracellular PH Reduction Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Dendritic Spine Development Potassium Ion Transmembrane Transport Ammonium Transmembrane Transport Postsynaptic Neurotransmitter Receptor Diffusion Trapping Regulation Of Postsynapse Assembly Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Negative Regulation Of Gene Expression UDP-glucose Transmembrane Transport Fucosylation Protein O-linked Glycosylation Via Fucose Positive Regulation Of Notch Signaling Pathway
Pathways		Cation-coupled Chloride cotransporters
Drugs		Potassium chloride Bumetanide
Diseases
GWAS		Chronotype ( 30696823) Crohn's disease ( 28067908) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 32888494) Systemic sclerosis ( 29293537) Triglyceride levels ( 32154731)
Interacting Genes		2 interacting genes: CCR4 F2RL1	123 interacting genes: ACSL5 ADIPOQ AGPAT3 AGPAT4 APOD APOL2 APOL3 ARL6IP1 ARLN ASGR1 ATP13A1 BCL2L2 BET1 BMP10 BTN2A2 C14orf180 C1GALT1 C2 CCDC167 CLDN19 CMTM5 CNIH1 COL4A5 CREB3 CREB3L1 CYB561 CYB5B CYBC1 DNAJC30 EFNA5 EMC6 EMD EMP3 FA2H FAM3C FDFT1 FFAR2 FXYD3 FXYD6 FXYD6-FXYD2 GIMAP5 GOLT1A GOSR2 GPR152 IGFBP5 INSIG2 ITGAM LAT LEPROTL1 LHFPL5 LPAR3 MAL MAL2 MALL MS4A1 NINJ2 NKG7 NRM ORMDL1 ORMDL2 ORMDL3 PDCD1LG2 PEX16 PLLP PLN PLP1 PLP2 PNLIPRP1 PRB1 RTP2 RUSF1 SACM1L SCD SEC22A SEC22B SELENOK SERP1 SLC10A6 SLC12A7 SLC30A3 SLC35F1 SLC38A7 SLC66A1 SMCO4 SSMEM1 STATH STRIT1 STX3 STX8 SYNDIG1 SYS1 TAP1 TECR TF THBD TMEM107 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM239 TMEM31 TMEM50B TMEM60 TMEM65 TMEM86A TMEM97 TPRG1 TSNARE1 TSPAN2 TSPAN33 TSPO2 TVP23B UNC93B1 UPK1B VAMP4 VEGFA VTI1B YIF1A YIPF4 YIPF6
Entrez ID		57468	51006
HPRD ID		09469	15371
Ensembl ID		ENSG00000124140	ENSG00000080189
Uniprot IDs		Q9H2X9	B7Z6R4 Q9NQQ7
PDB IDs		6M23 7D8Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytosolic Calcium Ion Concentration Phosphatidylinositol-3,5-bisphosphate Binding Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Histone H1 Reader Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Chromatin Lock Complex SAM Domain Binding UDP-glucose Transmembrane Transport Calcium-mediated Signaling Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Mature Conventional Dendritic Cell Differentiation Regulation Of Neutrophil Mediated Cytotoxicity Negative Regulation Of Macromolecule Metabolic Process Regulation Of System Process Positive Regulation Of Killing Of Cells Of Another Organism Thrombin-activated Receptor Activity Regulation Of Muscle Contraction Z Disc Histone H4K20me2 Reader Activity Protein O-linked Glycosylation Via Fucose Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Junctional Membrane Complex Regulation Of Cardiac Muscle Tissue Development	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNAP Receptor Activity Cellular Localization Structural Constituent Of Myelin Sheath Protein Binding Endomembrane System SNARE Complex Myelination Axon Ensheathment Membrane Fusion Golgi Membrane Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Establishment Of Protein Localization Membrane Organization Organelle Fusion Golgi Vesicle Transport Negative Regulation Of Sphingolipid Biosynthetic Process Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion Establishment Of Localization In Cell Vesicle Fusion With Golgi Apparatus Serine Palmitoyltransferase Complex Establishment Of Protein Localization To Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Positive Regulation Of Transport Lipid Biosynthetic Process Chemical Homeostasis Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Presynaptic Endosome Membrane Regulation Of Transport Protein Transport SNARE Binding Localization Within Membrane Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Respiratory Burst After Phagocytosis Regulation Of Membrane Lipid Metabolic Process Regulation Of Cellular Localization Membrane Docking Cholesterol Binding Vesicle Organization Lipid Metabolic Process Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Potassium:chloride Symporter Activity
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