PTGFR and NOC2L

		PTGFR	NOC2L
Description		prostaglandin F receptor	NOC2 like nucleolar associated transcriptional repressor
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Membrane	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Noc1p-Noc2p Complex Noc2p-Noc3p Complex
	Molecular Function	G Protein-coupled Receptor Activity Prostaglandin F Receptor Activity	Chromatin Binding Transcription Corepressor Activity RNA Binding Protein Binding Nucleosome Binding Histone Binding DNA-binding Transcription Factor Binding
	Biological Process	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Parturition Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Response To Estradiol Response To Lipopolysaccharide Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Prostaglandin D Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of B Cell Apoptotic Process Apoptotic Process Cellular Response To UV Ribosomal Large Subunit Biogenesis Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Prostanoid ligand receptors G alpha (q) signalling events	Regulation of TP53 Activity through Phosphorylation
Drugs		Travoprost Latanoprost Bimatoprost Dinoprost tromethamine Tafluprost Latanoprostene bunod
Diseases
GWAS		Bipolar disorder ( 22182935) Depression in multiple sclerosis (post-diagnosis) ( 33296963) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Skin fluorescence in type 1 diabetes ( 27207532) Systolic blood pressure (alcohol consumption interaction) ( 24376456)	California verbal learning test score ( 31596458) Pancreatic cancer ( 29422604)
Interacting Genes		5 interacting genes: AGTR1 PTGDS PTGER1 PTGER2 PTGES2	11 interacting genes: APP ATN1 ATXN7 H2AC18 H2BP1 H3-4 H4C16 LRIF1 PPP1CA RBFOX1 RNF10
Entrez ID		5737	26155
HPRD ID		08988	13166
Ensembl ID		ENSG00000122420	ENSG00000188976
Uniprot IDs		P43088	Q9Y3T9
PDB IDs		8IQ4 8IQ6 8IUK 8IUL 8IUM 8XJK 8XJL 8XJM	8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Prostaglandin E Receptor Activity Prostaglandin Biosynthetic Process Prostanoid Biosynthetic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Angiotensin Type I Receptor Activity L-cystine L-cysteine-lyase (deaminating) L-cysteine Desulfhydrase Activity Homocysteine Desulfhydrase Activity Selenocystathionine Gamma-lyase Activity Cystathionine Gamma-lyase Activity Carboxylic Acid Biosynthetic Process Protein Sulfhydration Protein-pyridoxal-5-phosphate Linkage Via Peptidyl-N6-pyridoxal Phosphate-L-lysine Prostanoid Metabolic Process Prostaglandin Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Icosanoid Biosynthetic Process Response To Prostaglandin E Fucose-1-phosphate Guanylyltransferase Activity Efferent Axon Development In A Lateral Line Nerve Medullary Reticular Formation Development Retrotrapezoid Nucleus Neuron Differentiation Ribosomal Large Subunit Biogenesis Noc2p-Noc3p Complex Noc1p-Noc2p Complex G Protein-coupled Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Cysteine Biosynthetic Process Via Cystathionine Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Parasympathetic Nervous System Development Cellular Response To Carbon Dioxide Negative Regulation Of Type B Pancreatic Cell Proliferation Response To Carbon Dioxide Protein Phosphatase Binding IkappaB Kinase Activity 12-hydroxyheptadecatrienoic Acid Synthase Activity Prostaglandin-E Synthase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Small Molecule Biosynthetic Process Cysteine Biosynthetic Process Transsulfuration	Chromosome, Telomeric Region Chromatin Remodeling Response To Lead Ion Transition Metal Ion Binding Protein Heterodimerization Activity Nucleosome Structural Constituent Of Chromatin Nuclear Matrix Chromatin Organization Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Gene Expression Positive Regulation Of Toll Signaling Pathway Prostaglandin F Receptor Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Carbohydrate Catabolic Process Chromosome Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Nucleus PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Synapse Structure Or Activity Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Regulation Of Toll Signaling Pathway Growth Factor Receptor Binding
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