PSMD1 and ZFAND1

Number of citations of the paper that reports this interaction (PubMedID 29804830)
0

Data Source:
BioGRID (pull down)

		PSMD1	ZFAND1
Description		proteasome 26S subunit, non-ATPase 1	zinc finger AN1-type containing 1
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GO Annotations	Cellular Component	Proteasome Complex Extracellular Region Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Proteasome Storage Granule Azurophil Granule Lumen	Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	Protein Binding Enzyme Regulator Activity Ubiquitin Protein Ligase Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Proteasome Binding
	Biological Process	Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Cellular Response To Oxidative Stress Cellular Response To Heat Stress Granule Disassembly Cellular Response To Osmotic Stress Positive Regulation Of Intracellular Protein Transport Cellular Response To Arsenite Ion
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Proportion of activated microglia (midfrontal cortex) ( 30679421)	Ovarian cancer ( 23535730)
Interacting Genes		12 interacting genes: ADRM1 APC BAG1 CAPN3 ESR1 HSPB1 NRIP1 SMAD1 STUB1 TRAF6 WEE2-AS1 ZFAND1	5 interacting genes: ERBB2 GPR35 PSMA1 PSMC4 PSMD1
Entrez ID		5707	79752
HPRD ID		10169	07847
Ensembl ID		ENSG00000173692	ENSG00000104231
Uniprot IDs		Q99460	Q8TCF1
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5V1Y 5V1Z 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6CO4 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6OI4 6UYI 6UYJ 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 8USD 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	7Y39 7Y7L 7YAB 8HW9 8XE8
Enriched GO Terms of Interacting Partners?		Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Response To Heat Regulation Of Protein Modification Process Ubiquitin Protein Ligase Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Smooth Muscle Cell Apoptotic Process Ubiquitin-ubiquitin Ligase Activity Proteasome Binding Z Disc Response To Temperature Stimulus Protein-containing Complex Organization Negative Regulation Of Apoptotic Process Protein Kinase Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Cytosol Cellular Response To Estradiol Stimulus Nuclear Estrogen Receptor Binding Ovulation Cycle Process Protein Catabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Calcium-dependent Self Proteolysis Cellular Response To Osmotic Stress Regulation Of Post-translational Protein Modification Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Protein Kinase C Signaling Ovarian Follicle Rupture Cellular Response To Heat Positive Regulation Of Chaperone-mediated Protein Complex Assembly Enzyme-linked Receptor Protein Signaling Pathway Proteasome Complex Protein-containing Complex Assembly Protein Autoubiquitination Cell Surface Receptor Signaling Pathway Response To Osmotic Stress Protein K63-linked Ubiquitination Regulation Of MiRNA Transcription Nucleus Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Homomeric SMAD Protein Complex Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction	Proteasome Complex Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process ERBB3:ERBB2 Complex Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Proteasome Storage Granule RNA Polymerase I Core Binding Negative Regulation Of Immature T Cell Proliferation In Thymus ErbB-3 Class Receptor Binding Immature T Cell Proliferation In Thymus ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Immature T Cell Proliferation Proteasome-activating Activity ERBB2-EGFR Signaling Pathway C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Macromolecule Catabolic Process Proteasome Core Complex, Alpha-subunit Complex ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Negative Regulation Of T Cell Differentiation In Thymus Proteolysis Regulation Of Immature T Cell Proliferation In Thymus Protein Metabolic Process Proteasome Regulatory Particle Semaphorin Receptor Complex Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Protein Catabolic Process
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