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PSMD1
Gene Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Membrane
Proteasome Accessory Complex
Extracellular Vesicular Exosome
Molecular Function
Enzyme Regulator Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Protein Catabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Bortezomib
Diseases
GWAS
Protein-protein Interactions
7 interactors:
ADRM1
APC
BAG1
PSMA3
SMAD1
TRAF6
UBC
Entrez ID
5707
HPRD ID
10169
Ensembl ID
ENSG00000173692
Uniprot IDs
Q99460
PDB IDs
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Regulation Of Apoptotic Process
Regulation Of Cell Death
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Apoptotic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Protein Metabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Mitotic Cell Cycle Checkpoint
Positive Regulation Of Apoptotic Process
Protein Polyubiquitination
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Negative Regulation Of Wnt Signaling Pathway
Regulation Of Proteolysis
Regulation Of Protein Ubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Canonical Wnt Signaling Pathway
MAPK Cascade
Antigen Processing And Presentation Of Peptide Antigen
Regulation Of Cell Cycle Phase Transition
Cell Cycle Checkpoint
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Negative Regulation Of Cellular Protein Metabolic Process
Cell Cycle Phase Transition
Signal Transduction By Phosphorylation
Intracellular Signal Transduction
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Antigen Processing And Presentation
Negative Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis
Regulation Of Wnt Signaling Pathway
Negative Regulation Of Transferase Activity
Tagcloud
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26s
ac
adenocarcinomas
atypical
carcinoid
cleaved
differently
glioblastoma
greatest
investigates
ki67
lcnec
lcnlc
microarrays
neuroendocrine
proliferative
proteasomal
psma1
psma5
psmb4
psmb5
pulmonary
regardless
sclc
taqman
tc
tma
tumours
unlike