Wiki-Pi
About
Search
People
Updates
Search
PSMD1 and ADRM1
Number of citations of the paper that reports this interaction (PubMedID
18497817
)
39
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
PSMD1
ADRM1
Description
proteasome 26S subunit, non-ATPase 1
ADRM1 26S proteasome ubiquitin receptor
Image
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Proteasome Storage Granule
Azurophil Granule Lumen
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Proteasome Regulatory Particle, Lid Subcomplex
Molecular Function
Protein Binding
Enzyme Regulator Activity
Ubiquitin Protein Ligase Binding
Protease Binding
Protein Binding
Endopeptidase Activator Activity
Proteasome Binding
Molecular Function Inhibitor Activity
Biological Process
Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Transcription Elongation By RNA Polymerase II
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasome Assembly
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS
Proportion of activated microglia (midfrontal cortex) (
30679421
)
Prostate cancer (
23535732
)
Interacting Genes
12 interacting genes:
ADRM1
APC
BAG1
CAPN3
ESR1
HSPB1
NRIP1
SMAD1
STUB1
TRAF6
WEE2-AS1
ZFAND1
23 interacting genes:
APP
ATP6V0D2
CDC42
DDI1
EGFR
MAILR
MX1
PRKN
PSMD1
PSMD14
PSMD2
PSMD4
RAD23A
RAD23B
RPN1
RPN2
SGTA
SMURF1
STUB1
UBE3A
UBQLN1
UBQLN2
UCHL5
Entrez ID
5707
11047
HPRD ID
10169
06440
Ensembl ID
ENSG00000173692
ENSG00000130706
Uniprot IDs
Q99460
A0A087WX59
Q16186
PDB IDs
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5V1Y
5V1Z
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6CO4
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6OI4
6UYI
6UYJ
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
8USD
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
2KQZ
2KR0
2L5V
2MKZ
2NBV
4UEL
4UEM
4WLQ
4WLR
5IRS
5V1Y
5V1Z
5YMY
6CO4
6OI4
6UYI
6UYJ
7KXI
8FTQ
Enriched GO Terms of Interacting Partners
?
Regulation Of Smooth Muscle Cell Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Response To Heat
Regulation Of Protein Modification Process
Ubiquitin Protein Ligase Binding
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Ubiquitin-ubiquitin Ligase Activity
Proteasome Binding
Z Disc
Response To Temperature Stimulus
Protein-containing Complex Organization
Negative Regulation Of Apoptotic Process
Protein Kinase Binding
Negative Regulation Of Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Cytosol
Cellular Response To Estradiol Stimulus
Nuclear Estrogen Receptor Binding
Ovulation Cycle Process
Protein Catabolic Process
Positive Regulation Of Metabolic Process
Intracellular Signal Transduction
Calcium-dependent Self Proteolysis
Cellular Response To Osmotic Stress
Regulation Of Post-translational Protein Modification
Negative Regulation Of Muscle Cell Apoptotic Process
Negative Regulation Of Protein Kinase C Signaling
Ovarian Follicle Rupture
Cellular Response To Heat
Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Enzyme-linked Receptor Protein Signaling Pathway
Proteasome Complex
Protein-containing Complex Assembly
Protein Autoubiquitination
Cell Surface Receptor Signaling Pathway
Response To Osmotic Stress
Protein K63-linked Ubiquitination
Regulation Of MiRNA Transcription
Nucleus
Ligase Regulator Activity
Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration
Protein-containing Complex
Negative Regulation Of Intracellular Signal Transduction
Homomeric SMAD Protein Complex
Regulation Of Multicellular Organismal Process
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Signal Transduction
Proteasomal Protein Catabolic Process
Proteasome Complex
Regulation Of Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Catabolic Process
Regulation Of Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis
Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Catabolic Process
Polyubiquitin Modification-dependent Protein Binding
Positive Regulation Of Response To Endoplasmic Reticulum Stress
Regulation Of Response To Endoplasmic Reticulum Stress
Proteasome Accessory Complex
Positive Regulation Of Proteasomal Protein Catabolic Process
Proteasome Binding
Positive Regulation Of ERAD Pathway
Positive Regulation Of Protein Catabolic Process
Regulation Of ERAD Pathway
Positive Regulation Of Protein Metabolic Process
ERAD Pathway
Kinase Binding
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Response To Stress
Positive Regulation Of Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Cytosol
Macromolecule Metabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome Storage Granule
Regulation Of Macroautophagy
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Response To Endoplasmic Reticulum Stress
Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity
Regulation Of Spontaneous Synaptic Transmission
Positive Regulation Of Post-translational Protein Modification
Oligosaccharyltransferase Complex B
Positive Regulation Of Cell Growth
Cellular Response To Manganese Ion
Oligosaccharyltransferase Complex A
Ubiquitin Protein Ligase Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?