UTP3 and DVL3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		UTP3	DVL3
Gene Name		UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)	dishevelled segment polarity protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Small-subunit Processome	Cytosol
	Molecular Function	Poly(A) RNA Binding	Protease Binding Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Protein Heterodimerization Activity
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Brain Development Chromatin Modification	Positive Regulation Of Protein Phosphorylation Outflow Tract Septum Morphogenesis Wnt Signaling Pathway Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of Transcription, DNA-templated Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL negative regulation of TCF-dependent signaling by DVL-interacting proteins Signaling by Wnt Signaling by WNT in cancer PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		5 interactors: CDCA7L DVL3 HAP1 PTN ZHX1	48 interactors: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		57050	1857
HPRD ID		18016	03222
Ensembl ID		ENSG00000132467	ENSG00000161202
Uniprot IDs		Q9NQZ2	Q92997
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Non-canonical Wnt Signaling Pathway Via JNK Cascade Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Non-canonical Wnt Signaling Pathway Via MAPK Cascade Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Hypothalamus Cell Differentiation Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Outflow Tract Septum Morphogenesis Positive Regulation Of Synaptic Transmission, GABAergic Regulation Of Metabolic Process Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Telomere Maintenance Via Semi-conservative Replication Response To Drug Regulation Of Beta-amyloid Formation Regulation Of Transcription, DNA-templated Regulation Of Cilium Assembly Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid Precursor Protein Catabolic Process Telomere Maintenance Via Recombination Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cochlea Morphogenesis Hypothalamus Development Positive Regulation Of Organelle Assembly Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Anterograde Axon Cargo Transport Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Non-canonical Wnt Signaling Pathway Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cation Channel Activity DNA Catabolic Process, Exonucleolytic	Positive Regulation Of Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Gene Expression RNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Wnt Signaling Pathway RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Proteolysis Regulation Of Cellular Component Organization Cellular Macromolecule Biosynthetic Process Positive Regulation Of Protein Modification Process Macromolecule Biosynthetic Process Negative Regulation Of Binding Regulation Of Gene Expression Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Protein Complex Assembly
Tagcloud ?			achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Difference) ?			achieves adaptor analogous blockade dab2 encouraging erks grb2 igfi igfir influencing insufficient links mek nonredundant pharmacologic postreceptor relied responded sensitization sensitizing sevenless shc son sos synergized tracked unselected
Tagcloud (Intersection) ?