PAK6 and CDIN1

		PAK6	CDIN1
Description		p21 (RAC1) activated kinase 6	CDAN1 interacting nuclease 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Cellular Response To Starvation Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension	Erythrocyte Differentiation
Pathways		Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		19 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RHOJ RHOV SEMA3B SNX2 TPD52L1	2 interacting genes: ASF1B TRIP13
Entrez ID		56924	84529
HPRD ID		06426	13650
Ensembl ID		ENSG00000137843	ENSG00000186073
Uniprot IDs		Q9NQU5	A0A2R8Y7J6 A0A2R8YD89 A0A2R8YEZ2 H3BS01 Q9Y2V0
PDB IDs		2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Anatomical Structure Morphogenesis Developmental Process Cellular Response To Estrogen Stimulus Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Protein-containing Complex Protein Serine Kinase Activity Glutamatergic Synapse Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cell Communication Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Developmental Growth Involved In Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Prostate Gland Growth Response To Estrogen Mitotic Nuclear Membrane Disassembly Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Kinetochore Regulation Of Reproductive Process Positive Regulation Of Cell Migration Developmental Growth Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Reproductive Process Membrane Disassembly Nuclear Membrane Disassembly Leukocyte Differentiation GTP Binding Cell-cell Signaling Cellular Response To Oxygen-containing Compound Regulation Of Apoptotic Signaling Pathway	Male Gamete Generation Oocyte Maturation Synaptonemal Complex Assembly Spermatogenesis Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Gamete Generation Negative Regulation Of Meiotic Nuclear Division Synaptonemal Complex Organization Female Meiosis I Male Meiosis I Regulation Of Meiotic Nuclear Division Reciprocal Meiotic Recombination Meiotic Recombination Checkpoint Signaling Negative Regulation Of Meiotic Cell Cycle Meiotic Cell Cycle Checkpoint Signaling Female Meiotic Nuclear Division DNA Replication-dependent Chromatin Assembly Histone Chaperone Activity Blastocyst Hatching Neuron Projection Arborization Meiosis I Homologous Recombination Negative Regulation Of Mitotic Nuclear Division Developmental Process Involved In Reproduction Oogenesis Male Meiotic Nuclear Division Male Germ Cell Nucleus Chromosome Organization Involved In Meiotic Cell Cycle Regulation Of Mitotic Sister Chromatid Separation
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