THAP10 and PTS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		THAP10	PTS
Description		THAP domain containing 10	6-pyruvoyltetrahydropterin synthase
Image		No pdb structure
GO Annotations	Cellular Component		Cytoplasm Mitochondrion Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	6-pyruvoyltetrahydropterin Synthase Activity Protein Binding Lyase Activity Identical Protein Binding Metal Ion Binding
	Biological Process		Amino Acid Metabolic Process Tetrahydrobiopterin Biosynthetic Process Central Nervous System Development Tetrahydrobiopterin Metabolic Process
Pathways			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Mycophenolate mofetil Biopterin
Diseases			Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Heel bone mineral density ( 30598549) Objective response to lithium treatment ( 26503763)
Interacting Genes		13 interacting genes: CCNDBP1 DYNLL1 DYNLL2 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 LZTS2 NME7 PLEKHF2 PSME3 PTS	11 interacting genes: AP2M1 COIL DDIT4L FNDC5 FXR2 LNX1 NTAQ1 PBRM1 PRKG2 SDCBP THAP10
Entrez ID		56906	5805
HPRD ID		15497	11840
Ensembl ID		ENSG00000129028	ENSG00000150787
Uniprot IDs		Q9P2Z0	Q03393
PDB IDs			3I2B
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Cytosol Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Dynein Complex Microtubule Associated Complex 6-pyruvoyltetrahydropterin Synthase Activity Ciliary Tip Intraciliary Transport Cilium Primary Ureteric Bud Growth Myosin V Complex Identical Protein Binding Centrosome Scaffold Protein Binding Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Deoxyribonuclease Inhibitor Activity Microtubule Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Proteasome Activator Complex Microtubule-based Process
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