ERO1B and HMGCS2

		ERO1B	HMGCS2
Description		endoplasmic reticulum oxidoreductase 1 beta	3-hydroxy-3-methylglutaryl-CoA synthase 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Protein-disulfide Reductase Activity Disulfide Oxidoreductase Activity Oxidoreductase Activity Thiol Oxidase Activity Unfolded Protein Binding FAD Binding	Hydroxymethylglutaryl-CoA Synthase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding
	Biological Process	Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Insulin Processing Extracellular Matrix Organization Protein Folding In Endoplasmic Reticulum Glucose Homeostasis Cell Redox Homeostasis Protein Maturation	Kidney Development Liver Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Midgut Development Response To Nutrient Steroid Metabolic Process Cholesterol Metabolic Process Isoprenoid Biosynthetic Process Response To Temperature Stimulus Response To Xenobiotic Stimulus Response To Bacterium Response To Metal Ion Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Sterol Biosynthetic Process Lung Development Response To Insulin Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Multicellular Organismal Response To Stress Response To Testosterone Response To Glucagon Response To Triglyceride Response To Monosaccharide Response To Prostaglandin F Response To Starvation Response To Peptide Hormone Response To Ethanol Ketone Body Biosynthetic Process Response To Glucocorticoid Response To CAMP Response To Growth Hormone Adipose Tissue Development Response To Fatty Acid Response To Linoleic Acid Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Fatty Acid
Pathways		Insulin processing	PPARA activates gene expression Synthesis of Ketone Bodies Mitochondrial protein degradation
Drugs		1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
Diseases			HMG-CoA synthase (HMGCS) deficiency
GWAS			Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Macular telangiectasia type 2 ( 33654266) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: BRCA1 ERP44 OGT P4HB	3 interacting genes: APP FBXO7 HSD17B10
Entrez ID		56605	3158
HPRD ID		13279	02580
Ensembl ID		ENSG00000086619	ENSG00000134240
Uniprot IDs		Q86YB8	A0A140VJL2 P54868
PDB IDs			2WYA
Enriched GO Terms of Interacting Partners?			Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Protein Tetramerization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Type II Interferon Production Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Phosphoanandamide Dephosphorylation Regulation Of Non-canonical NF-kappaB Signal Transduction Leukocyte Activation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Regulation Of Cell Activation Regulation Of Type II Interferon Production Endosome To Plasma Membrane Transport Vesicle Regulation Of Interleukin-6 Production Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Lewy Body Core Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Tumor Necrosis Factor Production Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Positive Regulation Of ERK1 And ERK2 Cascade
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