TMPRSS15 and GABPA

		TMPRSS15	GABPA
Description		transmembrane serine protease 15	GA binding protein transcription factor subunit alpha
Image			No pdb structure
GO Annotations	Cellular Component	Brush Border Membrane	Chromatin Nucleus Nucleoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Proteolysis	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Blastocyst Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases		Enterokinase deficiency
GWAS		Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)	Glaucoma (primary open-angle) ( 33627673) Gout (normal type) ( 32238385) Nicotine dependence symptom count ( 25555482)
Interacting Genes		1 interacting genes: SPINK1	14 interacting genes: APP ATF1 CEBPA CREBBP EP300 GABPB1 HCFC1 MED1 OGT PINX1 SP1 SP3 STK16 ZC2HC1B
Entrez ID		5651	2551
HPRD ID		05972	11793
Ensembl ID		ENSG00000154646	ENSG00000154727
Uniprot IDs		P98073	A8IE48 Q06546 Q8IYS3
PDB IDs		4DGJ 6ZOV 7WQX
Enriched GO Terms of Interacting Partners?		Phosphoribosylamine-glycine Ligase Activity Phosphoribosylformylglycinamidine Cyclo-ligase Activity Phosphoribosylglycinamide Formyltransferase Activity Ligase Activity, Forming Carbon-nitrogen Bonds Adenine Biosynthetic Process Negative Regulation Of Nitric Oxide Mediated Signal Transduction Adenine Metabolic Process	Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Acetyltransferase Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Protein-DNA Complex Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Hemopoiesis DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Placenta Development Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Nucleoplasm Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Protein Localization To Nucleus Transcription Coactivator Binding Regulation Of Glycolytic Process Chromatin Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Myeloid Cell Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Defense Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of ATP Metabolic Process STAT Family Protein Binding NSL Complex
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