PCDHA6 and RELN

Number of citations of the paper that reports this interaction (PMID 10612399)
24

Data Source:
HPRD (in vitro)

		PCDHA6	RELN
Gene Name		protocadherin alpha 6	reelin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane	Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Dendrite
	Molecular Function	Calcium Ion Binding	Protein Serine/threonine/tyrosine Kinase Activity Serine-type Peptidase Activity Metal Ion Binding Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development	Cell Morphogenesis Involved In Differentiation Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Long-term Memory Associative Learning Glial Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Dendrite Development Peptidyl-tyrosine Phosphorylation Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Positive Regulation Of TOR Signaling Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Regulation Of Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Synapse Maturation N-methyl-D-aspartate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease ( 20452100) Multiple sclerosis (age of onset) ( 19010793) Otosclerosis ( 19230858) Schizophrenia ( 18282107)
Protein-Protein Interactions		1 interactors: RELN	6 interactors: DAB1 LRP8 PCDHA4 PCDHA6 SQSTM1 VLDLR
Entrez ID		56142	5649
HPRD ID		07324	02742
Ensembl ID		ENSG00000081842	ENSG00000189056
Uniprot IDs		Q9UN73	P78509
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Lateral Motor Column Neuron Migration Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Long-term Synaptic Potentiation Lateral Motor Column Neuron Migration Spinal Cord Motor Neuron Migration N-methyl-D-aspartate Receptor Clustering Reelin-mediated Signaling Pathway Regulation Of Long-term Synaptic Potentiation Receptor Localization To Synapse Postsynaptic Density Protein 95 Clustering Cerebral Cortex Tangential Migration Positive Regulation Of Neuron Migration Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Positive Regulation Of CREB Transcription Factor Activity Protein Localization To Synapse Regulation Of Synapse Maturation Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Positive Regulation Of TOR Signaling Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendritic Spine Development Postsynaptic Membrane Organization Regulation Of Dendritic Spine Morphogenesis Spinal Cord Patterning Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Dendrite Morphogenesis Response To Pain Layer Formation In Cerebral Cortex Positive Regulation Of Receptor Activity Positive Regulation Of Membrane Potential Long-term Memory Cerebral Cortex Radial Glia Guided Migration Regulation Of Dendritic Spine Development Positive Regulation Of Ion Transmembrane Transporter Activity Receptor Clustering Regulation Of Neuron Migration Positive Regulation Of Transporter Activity Ventral Spinal Cord Development Positive Regulation Of Dendrite Development Regulation Of TOR Signaling Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Regulation Of Synaptic Transmission, Glutamatergic Glial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Dendrite Morphogenesis	Reelin-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Nervous System Development Positive Regulation Of Neuron Differentiation Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Projection Development Ventral Spinal Cord Development Positive Regulation Of Dendrite Development Positive Regulation Of Neurogenesis Positive Regulation Of Protein Metabolic Process Cerebral Cortex Radially Oriented Cell Migration Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Developmental Process Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Positive Regulation Of Cell Development Regulation Of Phosphorus Metabolic Process Cerebral Cortex Cell Migration Regulation Of Neuron Differentiation Positive Regulation Of Transferase Activity Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Ammon Gyrus Development Telencephalon Cell Migration Forebrain Cell Migration Regulation Of Dendrite Development Spinal Cord Development Regulation Of Neurogenesis Cerebellum Structural Organization Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Cerebral Cortex Development Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Very-low-density Lipoprotein Particle Clearance Glycoprotein Transport Regulation Of Cell Development Positive Regulation Of Cell Differentiation System Development Regulation Of Protein Metabolic Process Spinal Cord Motor Neuron Migration Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Pallium Development Radial Glia Guided Migration Of Purkinje Cell Central Nervous System Development
Tagcloud ?			ancestral ap2 boxes caat codes conform duplication exons flanking gt hsp40 intron introns lacks microexon minigene polyadenylation positions pseudogene rdj1 reeler reelin repeats rule splice successive symbol tandemly tata
Tagcloud (Difference) ?			ancestral ap2 boxes caat codes conform duplication exons flanking gt hsp40 intron introns lacks microexon minigene polyadenylation positions pseudogene rdj1 reeler reelin repeats rule splice successive symbol tandemly tata
Tagcloud (Intersection) ?