PCDHA6 and RELN

Number of citations of the paper that reports this interaction (PubMedID 10612399)
0

Data Source:
HPRD (in vitro)

		PCDHA6	RELN
Description		protocadherin alpha 6	reelin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Dendrite Extracellular Matrix Neuron Projection Reelin Complex
	Molecular Function	Calcium Ion Binding Cell Adhesion Molecule Binding	Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Receptor Ligand Activity Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development	Cell Morphogenesis Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Learning Long-term Memory Locomotory Behavior Associative Learning Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Dendrite Development Cell Migration Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Cerebral Cortex Development Forebrain Development Positive Regulation Of TOR Signaling Protein Localization To Synapse Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Differentiation Response To Pain Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Synaptic Activity Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Synapse Maturation Positive Regulation Of Synapse Maturation Postsynaptic Density Assembly NMDA Glutamate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Motor Neuron Migration Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Interneuron Migration Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Neuron Migration
Pathways			Reelin signalling pathway
Drugs
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Neutrophil count ( 27863252) Schizophrenia ( 29483656) Sum basophil neutrophil counts ( 27863252)	Adult body size ( 32376654) Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Body size at age 10 ( 32376654) Intraocular pressure ( 29785010) LDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) Sjögren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		1 interacting genes: RELN	9 interacting genes: DAB1 EFNB2 EFNB3 LRP8 PCDHA4 PCDHA6 RSPH1 SQSTM1 VLDLR
Entrez ID		56142	5649
HPRD ID		07324	02742
Ensembl ID		ENSG00000081842	ENSG00000189056
Uniprot IDs		Q9UN73	P78509
PDB IDs			8G21
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Lateral Motor Column Neuron Migration Spinal Cord Motor Neuron Migration Very-low-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Receptor Binding Cerebral Cortex Tangential Migration Regulation Of Synaptic Activity NMDA Glutamate Receptor Clustering Postsynaptic Density Protein 95 Clustering Postsynaptic Density Assembly Positive Regulation Of Synapse Maturation Ventral Spinal Cord Development Postsynaptic Specialization Assembly Neurotransmitter-gated Ion Channel Clustering Reelin-mediated Signaling Pathway Motor Neuron Migration Positive Regulation Of Neuron Migration Interneuron Migration Response To Pain Layer Formation In Cerebral Cortex Postsynaptic Density Organization Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Long-term Synaptic Potentiation Postsynaptic Specialization Organization Regulation Of Synapse Maturation Cerebral Cortex Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Dendrite Morphogenesis Long-term Memory Positive Regulation Of Dendritic Spine Development Regulation Of Long-term Synaptic Potentiation Telencephalon Cell Migration Dendrite Development Regulation Of Dendritic Spine Morphogenesis Receptor Clustering Forebrain Cell Migration Regulation Of Neuron Migration Modulation Of Excitatory Postsynaptic Potential Receptor Localization To Synapse Regulation Of Dendritic Spine Development Long-term Synaptic Potentiation Protein Localization To Synapse Regulation Of Dendrite Morphogenesis Forebrain Development Hippocampus Development Multicellular Organismal Response To Stress Regulation Of Synaptic Transmission, Glutamatergic	Ventral Spinal Cord Development Reelin-mediated Signaling Pathway Nervous System Development Glutamatergic Synapse Reelin Receptor Activity Very-low-density Lipoprotein Particle Receptor Activity Regulation Of Neuron Projection Development System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Developmental Process Regulation Of Cell Projection Organization Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Dendrite Development Apolipoprotein Binding Layer Formation In Cerebral Cortex Negative Regulation Of Neuron Projection Development Cell Adhesion Cargo Receptor Activity Ephrin Receptor Binding Adult Walking Behavior Negative Regulation Of Cell Projection Organization Walking Behavior Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Projection Organization T Cell Costimulation Calcium Ion Binding Dendrite Morphogenesis Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Cell Projection Morphogenesis Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Neuron Projection Morphogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission Ammon Gyrus Development Cell Surface Receptor Signaling Pathway Regulation Of Synapse Organization Hippocampus Development Cerebellum Structural Organization Adult Locomotory Behavior Positive Regulation Of Aorta Morphogenesis Virus Receptor Activity Calcium-dependent Protein Binding Brown Fat Cell Proliferation Amphisome Regulation Of Neurogenesis Cell Adhesion Molecule Binding Regulation Of Anatomical Structure Morphogenesis Regulation Of Dendrite Development Lateral Motor Column Neuron Migration Radial Glia Guided Migration Of Purkinje Cell
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