SMG9 and FNTB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMG9	FNTB
Description		SMG9 nonsense mediated mRNA decay factor	farnesyltransferase, CAAX box, subunit beta
Image
GO Annotations	Cellular Component	Cytosol	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Protein Binding Identical Protein Binding	Catalytic Activity Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Peptide Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Eye Development In Utero Embryonic Development Brain Development Heart Development Negative Regulation Of Apoptotic Process	Lipid Metabolic Process Positive Regulation Of Cell Population Proliferation Protein Farnesylation Positive Regulation Of Cell Cycle Regulation Of Microtubule-based Movement
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS
Drugs			AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		Lymphocyte count ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010)	Blood trace element (Zn levels) ( 23720494) Eosinophil count ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 32888494 28017375) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010) Mean corpuscular volume ( 19862010 32888494 28017375 27863252) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		39 interacting genes: AGTRAP AK8 ARFIP2 CCDC57 CEP76 CMTM4 CTAG1A CTAG1B DGAT2L6 FNTB GOLGA2 GSG1 HSF2BP INCA1 KRT31 KRT34 KRTAP10-8 MTUS2 NFKBID PFDN5 PHF1 PLEKHG4 PNMA3 PPP2R3C PRKAR1B RASSF10 REL SLC17A9 SLC50A1 SYP TCF4 TRAF2 TRIM23 TRIM27 TRIP6 TSC1 TTC19 ZMYND12 ZNF655	17 interacting genes: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRABD3 KRAS PTP4A3 RAP2A RRAS2 SMG9 TLX3
Entrez ID		56006	2342
HPRD ID		07800	00608
Ensembl ID		ENSG00000105771	ENSG00000257365
Uniprot IDs		Q9H0W8	A0A384MEJ5 P49356
PDB IDs		6L54 6SYT 6Z3R 7PW4 7PW5 7PW7 7PW8 7PW9 8FE7	1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding	GDP Binding G Protein Activity GTPase Activity GTP Binding Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Dynein Complex Binding Regulation Of Long-term Neuronal Synaptic Plasticity Defense Response To Protozoan Regulation Of Rac Protein Signal Transduction Regulation Of Protein Localization To Membrane Microtubule Associated Complex Response To Protozoan Hydrolase Activity Protein-membrane Adaptor Activity Response To Mineralocorticoid L-serine-pyruvate Transaminase Activity Peptide Pheromone Maturation Alpha-tubulin Binding Hsp90 Protein Binding Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Oxalic Acid Secretion Microtubule Binding CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Microtubule-based Movement Protein Farnesyltransferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Protein Farnesyltransferase Complex Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Glial Cell Development GTPase Complex Regulation Of Dendrite Morphogenesis Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Small GTPase Mediated Signal Transduction Glyoxylate Catabolic Process Alanine-glyoxylate Transaminase Activity Protein Farnesylation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?