ACOT13 and MYDGF

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ACOT13	MYDGF
Name		acyl-CoA thioesterase 13	myeloid derived growth factor
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Spindle Cytosol Cytoskeleton	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus
	Molecular Function	Protein Binding Hydrolase Activity Metal Ion Binding Fatty Acyl-CoA Hydrolase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Protein Homotetramerization Negative Regulation Of Cold-induced Thermogenesis	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		Mitochondrial Fatty Acid Beta-Oxidation	XBP1(S) activates chaperone genes
Drugs		2-Undecanone	None
GWAS		Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: MYDGF NTAQ1 RBBP6 SPG21	13 interacting genes: ACOT13 BAG6 EIF3F HPCA HPCAL1 LCN2 MDM2 NCALD SGTA SGTB UBQLN1 UBQLN2 UBQLN4
Entrez ID		55856	56005
HPRD ID		07158	08415
Ensembl ID		ENSG00000112304	ENSG00000074842
Uniprot IDs		Q9NPJ3	Q969H8
PDB IDs		2F0X 2H4U 3F5O	6O6W 6SVK 6SVL
GO Terms Enriched among Interactors		Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Identical Protein Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Targeting To Membrane Regulation Of Receptor Internalization Response To Endoplasmic Reticulum Stress Autophagosome Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Catabolic Process Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Receptor-mediated Endocytosis Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Response To Iron Ion Molecular Adaptor Activity Regulation Of Macroautophagy Protein Targeting Establishment Of Protein Localization To Membrane Regulation Of Protein Metabolic Process Hsp70 Protein Binding