KMT2E and MAPRE2

		KMT2E	MAPRE2
Description		lysine methyltransferase 2E (inactive)	microtubule associated protein RP/EB family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytoskeleton Plasma Membrane Membrane Nuclear Body Nuclear Speck Protein-containing Complex Set3 Complex Rpd3L-Expanded Complex	Cytoplasm Microtubule Organizing Center Cytoskeleton Microtubule Cytoplasmic Microtubule Focal Adhesion Microtubule Cytoskeleton Microtubule Plus-end Spindle Midzone
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3 Methyltransferase Activity	Protein Binding Microtubule Binding Protein Kinase Binding Identical Protein Binding Microtubule Plus-end Binding
	Biological Process	Neutrophil Mediated Immunity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Erythrocyte Differentiation Epigenetic Regulation Of Gene Expression Neutrophil Activation Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of ARF Protein Signal Transduction Protein Localization To Microtubule Spindle Assembly Cell Division Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Disassembly
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)	Brugada syndrome ( 35210625) Cerebrospinal fluid AB1-42 levels ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Facial morphology ( 29921221) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: ASH2L ATP13A1 CDCA8 CDK1 CRK LAMTOR5	25 interacting genes: APC APP AURKA AURKB CASK CDK2 CDK4 CLASP2 CLIP1 DDIT4L FBXO7 GTSE1 LMNA LMO2 LNX1 MAPRE3 NIF3L1 PAXIP1 RBM10 RBM6 SLAIN2 TRAF1 TRAIP TXN2 UBC
Entrez ID		55904	10982
HPRD ID		10528	16157
Ensembl ID		ENSG00000005483	ENSG00000166974
Uniprot IDs		Q8IZD2	Q15555
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Midbody Regulation Of Metaphase Plate Congression Regulation Of Attachment Of Spindle Microtubules To Kinetochore Organelle Assembly Spindle Midzone Positive Regulation Of Chromosome Segregation Protein-containing Complex Pronuclear Fusion Spindle Cytoskeleton Organization DNA N6-methyladenine Demethylase Activity Extraction Of Mislocalized Protein From ER Membrane ABC-type Manganese Transporter Activity Membrane Protein Dislocase Activity Positive Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Mitotic DNA-templated DNA Replication Cellular Component Assembly Cyclin B1-CDK1 Complex Cilium Organization Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Helper T Cell Diapedesis Positive Regulation Of Intracellular Signal Transduction Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Small GTPase Mediated Signal Transduction Linoleic Acid Epoxygenase Activity Epigenetic Regulation Of Gene Expression Positive Regulation Of ARF Protein Signal Transduction Cleavage Furrow Ingression Intracellular Protein Localization Response To Activity Regulation Of Organelle Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome Organization Cyclin-dependent Protein Kinase Activity Cerebellar Neuron Development Response To Flavonoid P-type Transmembrane Transporter Activity Spindle Assembly Regulation Of Schwann Cell Differentiation Response To Hydrogen Peroxide Microtubule-based Process Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Protein Localization To Nucleus Response To Toxic Substance	Regulation Of Microtubule Polymerization Or Depolymerization Microtubule Plus-end Binding Regulation Of Microtubule-based Process Regulation Of Microtubule Cytoskeleton Organization Microtubule Cytoskeleton Microtubule-based Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Supramolecular Fiber Organization Cytoplasmic Microtubule Regulation Of Microtubule Polymerization Centrosome Microtubule Cytoskeleton Organization Kinetochore Cell Cycle Phase Transition Microtubule Plus-end Spindle Midzone Regulation Of Cell Cycle Process Microtubule Spindle Assembly Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Depolymerization Positive Regulation Of Cellular Component Organization Cytoskeleton Chromosome Passenger Complex Spindle Microtubule Microtubule Binding Regulation Of Organelle Organization Positive Regulation Of Mitotic Cell Cycle Cell Division Membraneless Organelle Assembly Mitotic Cell Cycle Phase Transition Ubiquitin Protein Ligase Binding Cell Cycle G2/M Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Identical Protein Binding Regulation Of Cell Cycle G1/S Phase Transition Protein Serine Kinase Activity Nuclear Lamina
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