KMT2E

Gene Name		lysine (K)-specific methyltransferase 2E
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Nuclear Speck Intracellular Membrane-bounded Organelle Intercellular Bridge MLL5-L Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Enzyme Binding Histone Methyltransferase Activity (H3-K4 Specific)
	Biological Process	Neutrophil Mediated Immunity DNA Methylation Chromatin Organization Transcription, DNA-templated Cell Cycle Arrest Erythrocyte Differentiation Positive Regulation Of Granulocyte Differentiation Neutrophil Activation Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Histone H3-K4 Methylation Cellular Response To Retinoic Acid
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: CDK1
Entrez ID		55904
HPRD ID		10528
Ensembl ID		ENSG00000005483
Uniprot IDs		Q8IZD2
PDB IDs		2LV9 4L58
Enriched GO Terms of Interacting Partners?		Pronuclear Fusion Regulation Of Schwann Cell Differentiation Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Ventricular Cardiac Muscle Cell Development Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Chromosome Positive Regulation Of Cardiac Muscle Cell Proliferation G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly Positive Regulation Of Heart Growth Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Cardiac Muscle Cell Proliferation Peptidyl-threonine Phosphorylation Chromosome Condensation Positive Regulation Of Organ Growth Response To Amine Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Activity Centrosome Cycle Response To Cadmium Ion Regulation Of Heart Growth Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Cardiac Muscle Tissue Development TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Striated Muscle Tissue Development Activation Of MAPKK Activity Positive Regulation Of Muscle Tissue Development Positive Regulation Of DNA Replication MyD88-independent Toll-like Receptor Signaling Pathway Nuclear Envelope Organization Toll-like Receptor 3 Signaling Pathway Response To Axon Injury Cardiac Muscle Cell Development MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Aging
Tagcloud ?		architectures arx autism broadening broadly cul4b determinants di diseased dysregulated h3k4 hundreds kdm5a kdm5c kmt2a kmt2c kmt2d list mark mll5 mono monoaminergic monogenic neurodevelopmental pathophysiology psychosis trimethylated upset widespread