NBEA

Description		neurobeachin
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GO Annotations	Cellular Component	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane
	Molecular Function	Protein Kinase Binding
	Biological Process	Intracellular Protein Localization
Pathways		Neurotransmitter receptors and postsynaptic signal transmission PKA activation NOTCH1 Intracellular Domain Regulates Transcription Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile) ( 28679651) Immunoglobulin light chain (AL) amyloidosis (serum IgG profile) ( 28679651) Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Non-muscle-invasive bladder cancer tumour size ( 31277774) Nonsyndromic cleft lip with or without cleft palate x sex interaction (2df test) ( 30277614) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Response to antipsychotic treatment in schizophrenia ( 29503163)
Interacting Genes		6 interacting genes: BMPR2 DSCR9 DTNBP1 PRKAR2A PRKAR2B STRN4
Entrez ID		26960
HPRD ID		05352
Ensembl ID		ENSG00000172915
Uniprot IDs		B3KXQ8 Q5T321 Q8NFP9
PDB IDs		1MI1
Enriched GO Terms of Interacting Partners?		Neuronal Cell Body CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Dendritic Spine CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Protein Domain Specific Binding Ciliary Base Regulation Of CAMP/PKA Signal Transduction Retina Development In Camera-type Eye Dendrite Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Response To Antipsychotic Drug Glutamatergic Synapse Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Signal Transduction Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Cell Communication Negative Regulation Of Chondrocyte Proliferation Venous Blood Vessel Development Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Axon Extension Involved In Axon Guidance Aortic Valve Development Endochondral Bone Morphogenesis Semi-lunar Valve Development Regulation Of Intracellular Signal Transduction Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Transforming Growth Factor Beta Receptor Activity Mitral Valve Morphogenesis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Postsynapse Armadillo Repeat Domain Binding Postsynaptic Density Negative Regulation Of Dendritic Spine Development Maternal Placenta Development Lung Vasculature Development Pharyngeal Arch Artery Morphogenesis Endothelial Cell Apoptotic Process
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