MAGEH1 and CDK5RAP2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MAGEH1	CDK5RAP2
Gene Name		melanoma antigen family H, 1	CDK5 regulatory subunit associated protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Pericentriolar Material Spindle Pole Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cell Junction Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Calmodulin Binding Microtubule Binding Tubulin Binding Protein Kinase Binding Transcription Regulatory Region DNA Binding
	Biological Process	Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule Bundle Formation Organelle Organization Chromosome Segregation Brain Development Neurogenesis Regulation Of Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Centrosome Organization Regulation Of Spindle Checkpoint
Pathways			Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Response to statin therapy ( 20339536)
Protein-Protein Interactions		14 interactors: APP CDK5RAP2 ELN HMBOX1 KPNA2 MOAP1 NAP1L5 NGFR PIAS4 TADA3 TNFRSF1A TNIP1 TRIM41 ZSCAN9	24 interactors: ABCA2 C14orf1 CDK5 CDK5R1 CRMP1 EEF1G FBXO25 HAP1 KAT5 LUC7L2 MAGEH1 MAPRE1 NEFL PCBD1 PTN RBM48 REPS2 SENP2 STARD9 STK36 TBC1D4 TRIM37 TSNAX ZPR1
Entrez ID		28986	55755
HPRD ID		06633	09740
Ensembl ID		ENSG00000187601	ENSG00000136861
Uniprot IDs		Q9H213	B3KVI2 B9EG74 Q7Z3M0 Q96SN8
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Neurogenesis Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Negative Regulation Of Cell Development Apoptotic Signaling Pathway Regulation Of Transcription, DNA-templated Synaptic Growth At Neuromuscular Junction Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Inflammatory Response Regulation Of RNA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Organelle Organization Positive Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway Collateral Sprouting In Absence Of Injury Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Hair Follicle Development Apoptotic Process Programmed Cell Death Regulation Of Tubulin Deacetylation Negative Regulation Of Centriole Replication Protein Insertion Into Mitochondrial Membrane Negative Regulation Of Hair Cycle Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Metabolic Process Cell Death Death Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Neuron Differentiation Regulation Of Cellular Component Organization Axon Choice Point Recognition Establishment Of Localization In Cell	Serine Phosphorylation Of STAT3 Protein Regulation Of Protein Binding Serine Phosphorylation Of STAT Protein Regulation Of Microtubule-based Process Retrograde Axon Cargo Transport Regulation Of Intracellular Transport Cell Projection Organization Regulation Of Neuron Apoptotic Process Regulation Of Cell Cycle Process Regulation Of Binding Limbic System Development Regulation Of Neuron Death Regulation Of Organelle Organization Axon Development Cerebellum Development Microtubule-based Movement Cellular Component Assembly Metencephalon Development Negative Regulation Of Axon Extension Movement Of Cell Or Subcellular Component Anterograde Axon Cargo Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Axonogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Intracellular Protein Transport Hindbrain Development Microtubule-based Process Layer Formation In Cerebral Cortex Positive Regulation Of Receptor Activity Nervous System Development Neuron Projection Development Cerebral Cortex Radial Glia Guided Migration Regulation Of Cell Morphogenesis Peptidyl-threonine Phosphorylation Negative Regulation Of Neuron Death Cell Projection Morphogenesis Regulation Of Dendritic Spine Development Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Pre-mRNA Catabolic Process DNA Endoreduplication Regulation Of Cell Projection Organization Cell Part Morphogenesis Axon Cargo Transport Regulation Of Cytoskeleton Organization Response To Organic Cyclic Compound Positive Regulation Of Intracellular Transport Regulation Of Cell Cycle Organelle Organization
Tagcloud ?			acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Difference) ?			acentrosomal associates centrosomal centrosomin contains fam128a gamma gcp2 impairs melanogaster microcephaly microtubule microtubules mto1p nme7 nucleating nucleation pcp1p pombe referred regrowth schizosaccharomyces stimulates tethering tubulin tuc tuna turc unaffected
Tagcloud (Intersection) ?