ZNF407 and STAT6

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZNF407	STAT6
Gene Name		zinc finger protein 407	signal transducer and activator of transcription 6, interleukin-4 induced
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleoplasm Cytoplasm Cytosol Membrane Raft
	Molecular Function	DNA Binding Zinc Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Positive Regulation Of Type I Interferon Production Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Proliferation Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Reactive Nitrogen Species
Pathways			Signaling by PDGF Downstream signal transduction Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS		Estradiol levels ( 22675492)	Eosinophilic esophagitis (pediatric) ( 20208534) IgE levels ( 22075330)
Protein-Protein Interactions		3 interactors: STAT6 ZBTB9 ZSCAN1	37 interactors: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 HIST2H3C IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		55628	6778
HPRD ID		11713	03302
Ensembl ID		ENSG00000215421	ENSG00000166888
Uniprot IDs		Q9C0G0	A8K4S9 B4DQB3 P42226
PDB IDs			1OJ5
Enriched GO Terms of Interacting Partners?		T-helper 1 Cell Lineage Commitment Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes T-helper Cell Lineage Commitment Transcription, DNA-templated T-helper 1 Cell Differentiation RNA Biosynthetic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Mammary Gland Epithelial Cell Proliferation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Isotype Switching T Cell Lineage Commitment Positive T Cell Selection RNA Metabolic Process T-helper 1 Type Immune Response T-helper Cell Differentiation Gene Expression Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Immunoglobulin Production CD4-positive, Alpha-beta T Cell Differentiation CD4-positive, Alpha-beta T Cell Activation T Cell Selection Cellular Response To Interleukin-4 Regulation Of Type 2 Immune Response Response To Interleukin-4 Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Hydrogen Peroxide Regulation Of RNA Metabolic Process Alpha-beta T Cell Differentiation Nucleobase-containing Compound Metabolic Process Regulation Of DNA Recombination Alpha-beta T Cell Activation T Cell Activation Involved In Immune Response Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of B Cell Activation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Mammary Gland Morphogenesis Positive Regulation Of Type I Interferon Production Epithelial Cell Proliferation Mammary Gland Epithelium Development	Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Gene Expression Regulation Of Gene Expression RNA Metabolic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Defense Response Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Immune Response Cellular Nitrogen Compound Metabolic Process Regulation Of Cytokine Production Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Response To Hormone Response To Stress Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Immune System Process Positive Regulation Of Cytokine Production Response To Cytokine Regulation Of Cellular Process Response To Biotic Stimulus Cellular Response To Hormone Stimulus Cellular Metabolic Process Innate Immune Response Regulation Of Cell Differentiation
Tagcloud ?			13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Difference) ?			13r 13ralpha 2rgammac 4r alternative chains classical consist consists crucial exist form forms gammac hand hematopoietic il instead jak1 jak3 lack predominantly recently regard signals transduction transmitted tyrosine utilized
Tagcloud (Intersection) ?