SMPD4 and NR4A2

		SMPD4	NR4A2
Description		sphingomyelin phosphodiesterase 4	nuclear receptor subfamily 4 group A member 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Sarcolemma	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Protein-containing Complex
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Hydrolase Activity Metal Ion Binding Sphingomyelin Phosphodiesterase D Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Nuclear Glucocorticoid Receptor Binding Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Sphingomyelin Catabolic Process Endoplasmic Reticulum Organization Glycerophospholipid Catabolic Process Ceramide Biosynthetic Process Cellular Response To Tumor Necrosis Factor	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Neuron Migration Response To Amphetamine DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Adult Locomotory Behavior Post-embryonic Development Gene Expression Regulation Of Gene Expression Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Differentiation Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Dopamine Metabolic Process Neuron Maturation Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Apoptotic Process General Adaptation Syndrome Canonical Wnt Signaling Pathway Cellular Response To Corticotropin-releasing Hormone Stimulus Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Glycosphingolipid catabolism	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		Phosphatidyl serine
Diseases			Parkinson's disease (PD)
GWAS			Age at voice drop ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Chronic obstructive pulmonary disease ( 30804561) Depression ( 29700475) HDL cholesterol levels ( 32109663) Leisure-time exercise behaviour ( 30102679) Leisure-time exercise behaviour (age-stratified) ( 30102679) Lung function (FEV1/FVC) ( 30061609) Menarche (age at onset) ( 21102462 25231870) Response to statin therapy ( 20339536) Schizophrenia ( 33169155) Sociability score ( 34054130) Worry too long after an embarrassing experience ( 34054130)
Interacting Genes		2 interacting genes: ERBB2 EXOSC4	16 interacting genes: BAZ1B CDKN1C CDKN2D COPS5 DSCR9 MAPK1 ODAD2 PIAS4 PPARG RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 TCEAL5 VHL
Entrez ID		55627	4929
HPRD ID		13374	03493
Ensembl ID		ENSG00000136699	ENSG00000153234
Uniprot IDs		A0A7P0TB24 Q9NXE4	F1D8N6 F1DAL2 P43354 Q53EL4
PDB IDs			1OVL 5Y41 5YD6 6DDA 6L6L 6L6Q 7WNH 8CYO
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Immature T Cell Proliferation In Thymus RNA Polymerase I Core Binding Positive Regulation Of Cell Growth Heart Development Negative Regulation Of T Cell Differentiation In Thymus Neuron Differentiation Regulation Of Cell Growth Negative Regulation Of Immature T Cell Proliferation ErbB-3 Class Receptor Binding Semaphorin Receptor Complex ERBB3:ERBB2 Complex Regulation Of Immature T Cell Proliferation In Thymus ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Growth ERBB3 Signaling Pathway Immature T Cell Proliferation In Thymus ERBB2-EGFR Signaling Pathway ERBB2-ERBB4 Signaling Pathway Protein Heterodimerization Activity ERBB4 Signaling Pathway Midbrain Dopaminergic Neuron Differentiation Habenula Development Nuclear Glucocorticoid Receptor Binding Cellular Response To Corticotropin-releasing Hormone Stimulus Dopamine Biosynthetic Process General Adaptation Syndrome Cytoplasmic Exosome (RNase Complex) Exoribonuclease Complex RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance DNA Deamination Nucleolar Exosome (RNase Complex) Activin Receptor Binding Nodal Binding Nodal Signaling Pathway Histone MRNA Catabolic Process Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Nuclear Retinoid X Receptor Binding Catecholamine Biosynthetic Process RRNA Catabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Maturation Of 5.8S RRNA Regulation Of Dopamine Metabolic Process Protein Localization To Postsynapse Regulation Of Protein Targeting To Membrane	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA Binding Domain Binding Chromatin Positive Regulation Of Lipoprotein Transport Nucleosome Array Spacer Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Intracellular Signal Transduction MRNA Transcription By RNA Polymerase II Transcription Coregulator Binding Positive Regulation Of Vitamin D Receptor Signaling Pathway Nuclear Receptor Activity LBD Domain Binding Retinoic Acid-responsive Element Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Vitamin D Receptor Signaling Pathway BBAF Complex System Development Peroxisome Proliferator Activated Receptor Signaling Pathway Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Cell Cycle Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction NpBAF Complex GBAF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Chromosome Organization NBAF Complex Positive Regulation Of Double-strand Break Repair Transcription Cis-regulatory Region Binding Nuclear Receptor-mediated Signaling Pathway Response To Retinoic Acid Monocyte Differentiation Regulation Of Cell Population Proliferation Nucleoplasm Positive Regulation Of DNA Metabolic Process
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